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Fig. 3 | Molecular Cancer

Fig. 3

From: LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

Fig. 3

LCT activity at single cell level in NSCLC. A The number of overlapped events determined between TCGA bulk RNAseq and single cell sequencing data sets. B UMAP plot of cells colored by cell type. C UMAP plot of cells colored by LCT activity. Red colored dots represent cells with LCT event detected. D The percentage of cells with LCT activity in each cell of each patient. The summary of each patient or each cell type tested is shown as the bar plot on the left and bottom. The UMAP (E) plot and pseudo time trajectory analysis (F) of tumor cells from patient 3 and patient 4 is shown. Red colored dots represent cells with LCT event detected. G Enriched GO termed of genes highly expressed in tumor subtype enriched with LCT events versus other tumor cells. (H) Enriched GO terms of genes highly expressed in LCT positive tumor cells versus LCT negative tumor cells

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Molecular Cancer

ISSN: 1476-4598