Fig. 4
L1-FGGY initiated arachidonic acid (AA) metabolism reprogramming and activated 12-LOX pathway in LUSC. A The KEGG pathway enrichment analysis of differential expression between L1-FGGY+ tissues and L1-FGGY− tissues based on RNAseq data from TCGA and an independent Chinese cohort of 109 LUSC tumor samples (52 L1-FGGY+ vs. 57 L1-FGGY−) from TJMUCH. B The gene expression profiles (log2 (count per million (CPM))) of the downstream key components involved in AA metabolism was compared between L1-FGGY+ tissues and L1-FGGY− tissues based on the RNAseq data. C The KEGG pathway enrichment analysis of differential expression between H520OV−L1−FGGY and H520OV−CTRL based on proteomics analysis. D The protein expression involved in different metabolic pathways was compared between H520OV−L1−FGGY and H520OV−CTRL based on proteomics analysis. E The KEGG pathway enrichment analysis of proteins with different fold changes between H520OV−L1−FGGY and H520OV−CTRL based on proteomics analysis. F The results of metabolomics assay targeting AA pathway metabolites were compared between H520OV−L1−FGGY and H520OV−CTRL. G The ELISA results of AA pathway metabolites from cells and tissues. The data are shown in plots. * and ** indicate p < 0.05 and p < 0.01, respectively between the groups as indicated