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Fig. 8 | Molecular Cancer

Fig. 8

From: LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

Fig. 8

Precision-guided evidence for lung cancer patients with a poor prognosis that correspond with high LCT activity. A Overall L1 expression in samples treated with NVR or ML355 are illustrated. L1 expression was normalized as read per million for each sample where the enriched GO terms of those genes whose expression decreased after treatment is noted. B The top drug candidates for the 46 LCT related genes. Heatmap shows the correlation score of each drug in each cell line predicted using the “Cmap” database. C Top panel shows the z-normalized expression of the 46 genes in all tumor samples. Middle panel shows the overall expression of LCT in two groups based on the expression of 46 genes. On the lower panel, two groups are divided into four based on the total expression value of survival related LCT in each sample. The mortality rate and number of mortality cases within 36 months of each group was labeled in each group

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Molecular Cancer

ISSN: 1476-4598