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Fig. 1 | Molecular Cancer

Fig. 1

From: CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma

Fig. 1

Downregulation of circGPR137B is associated with poor survival in patients with HCC. A CircRNA profiling analysis of the differentially-expressed circRNAs between HCC and adjacent normal tissues. B Heatmap analysis of 96 upregulated circRNAs and 51 downregulated circRNAs in HCC according to the restrictive conditions (P < 0.05 and FC > 1.5). C Volcano plot of a new substantially downregulated hsa_circ_0017114 (circGPR137B) in HCC tissues. D CircRNA profiling analysis of the expression of circGPR137B in 3 paired HCC tissues. E RT-qPCR analysis of the expression of circGPR137B in 5 paired HCC tissues. F, G FISH validation of the expression of circGPR137B in 87 paired HCC tissues. Blue color: DAPI; Green color: circGPR137B. H, I Kaplan–Meier analysis of the association of circGPR137B high or low expression with overall survival in HCC and early stage ones

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Molecular Cancer

ISSN: 1476-4598