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Fig. 11 | Molecular Cancer

Fig. 11

From: CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma

Fig. 11

Schematic illustration of circGPR137B suppressing proliferation and metastasis of liver cancer through a positive feedback loop. CircGPR137B induces FTO protein expression by sponging miR-4739 which binds to FTO mRNA in order to inhibit its expression. FTO protein enters into cellular nuclear to mediate m6A demethylation of circGPR137B and promotes its expression. Thus, a positive feedback forms on circGPR137B production, resulting in strongly repressing liver cancer cell proliferation, colony formation, invasion, and lung migration

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Molecular Cancer

ISSN: 1476-4598