Fig. 9

CircGPR137B inhibits in vivo HCC tumorigenesis. A Ex vivo imaging of the luciferase signals in tumors formed by stable transfection with circGPR137B or control group into luciferase-labeled HepG2 cells. B, C Schematic representation of the comparison of HepG2 xenograft tumors between circGPR137B and control groups and statistical analysis of the tumor size and weight between circGPR137B and control groups. D HE staining of the tumor tissue cells and IHC analysis of the Ki-67 proliferation index and FTO expression between circGPR137B and control groups. E RT-qPCR analysis of the expression levels of circGPR137B, miR-4739 and FTO between circGPR137B and control groups. F Schematic representation of the comparison of SK-hep-1 xenograft tumors between sh-circGPR137B and sh-NC groups, and statistical analysis of the tumor size and weight between sh-circGPR137B and sh-NC groups. G IHC analysis of the Ki-67 proliferation index and FTO expression levels between sh-circGPR137B and sh-NC groups. H. RT-qPCR analysis of the expression levels of circGPR137B, miR-4739 and FTO between sh-circGPR137B and sh-NC groups