Fig. 2

Impacts of m6A modification on biogenesis, export, degradation and translation of circRNAs. (1) Biogenesis: m6A sites located on pre-mRNAs are added by METTL3 (m6A writer), and can be identified by YTHDC1 (m6A reader), thus facilitating back-splicing and the biogenesis of circRNAs. (2) Export: the m6A reader YTHDC1 can also promote cytoplasmic export of circRNAs via interacting with m6A residues. (3) Degradation: m6A-modified circRNAs can be recognized by YTHDF2 (m6A reader), which participates in the formation of cleavage complex with HRSP12 and RNase P/MRP, resulting in the degradation of circRNAs. (4) Translation: YTHDF3 (m6A reader) and eIF4G2 are essential for the initiation of m6A-modified circRNAs translation