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Fig. 3 | Molecular Cancer

Fig. 3

From: Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

Fig. 3

M6A modulators regulate therapeutic resistance in cancer. M6A modification is dynamically modulated by m6A writers, erasers and readers, and these m6A modulators play vital roles in therapeutic resistance. (1) In chemotherapy: m6A modification can reduce chemosensitivity through facilitating autophagy, DNA damage repair, CSC properties, drug efflux and glycolysis. (2) In radiotherapy: m6A modification can promote radioresistance via improving CSC properties and DNA damage repair. (3) In targeted therapy: m6A modification can increase drug efflux, suppress drug influx and apoptosis, thereby weakening the efficacy of target therapy. (4) In immunotherapy: m6A modification can remodel the TME, and further lead to immunotherapy resistance

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