Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

Fig. 5

The role of m6A-modified circRNAs in cancer therapeutic resistance. M6A modification affects the biogenesis, translation and degradation of circRNAs, thus regulating the roles of circRNAs in therapeutic resistance of multiple cancers. (1) In HSCC: METTL3 elevated circCUX1 stability, leading to radioresistance. (2) In HCC: m6A regulators promoted circRNA-SORE stability and circMAP3K4 translation, resulting in sorafenib and cisplatin resistance, respectively. (3) In NSCLC: YTHDC1 and YTHDF2 facilitated anti-PD-L1 therapy and gefitinib resistance via increasing circIGF2BP3 biogenesis and circASK1 degradation, respectively

Back to article page

Molecular Cancer

ISSN: 1476-4598