Table 3 M6A-modified circRNAs in cancer therapeutic resistance
Cancer types | M6A regulators | Roles of m6A in circRNAs | Functions | Mechanisms | Ref. |
|---|---|---|---|---|---|
HSCC | METTL3 | Promotes m6A modification of circCUX1 to stabilizes its expression | Radiotherapy resistance | Decreases the release of inflammatory factors in TME | [52] |
HCC | m6A | Elevates circRNA-SORE expression via increasing RNA stability | Sorafenib resistance | Activates the Wnt/β-catenin pathway | [184] |
| Â | IGF2BP1 | Promotes m6A-modified circMAP3K4 translation | Cisplatin resistance | Inhibits apoptosis | [185] |
NSCLC | YTHDC1 | Facilitates the biogenesis of m6A-modified circIGF2BP3 | Anti-PD-L1 therapy resistance | Promotes tumor immune evasion | [186] |
| Â | YTHDF2 | Increases m6A-modified circASK1 degradation | Gefitinib resistance | Represses apoptosis | [51] |