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Table 4 CircRNAs affect m6A modification in cancer therapeutic resistance

From: Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

Cancer types

CircRNAs

Roles of circRNAs in m6A

Functions

Mechanisms

Ref.

Glioma

circ_0072083

Promotes ALKBH5 expression via sponging miR-1252-5p

Temozolomide resistance

Maintains glioma stem cells

[198]

CRC

circPTK2

Elevates YTHDF1 level by targeting miR-136-5p

5-FU/oxaliplatin resistance

–

[199]

HCC

circRHBDD1

Recruits YTHDF1

Anti-PD-1 therapy resistance

Elevates glycolysis

[200]

BC

circ0008399

Facilitates the formation of MTC through combining with WTAP

Cisplatin resistance

Boosts anti-apoptosis

[201]

 

circMORC3

Interacts with VIRMA and elevates global m6A level

Cisplatin resistance

Promotes DNA repair and suppresses DNA damage

[202]

Prostate cancer

circARHGAP29

Interacts with IGF2BP2

Docetaxel resistance

Promotes glycolysis

[156]