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Fig. 6 | Molecular Cancer

Fig. 6

From: E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer

Fig. 6

MAGI3 is negatively associated with c-Myc in CRC specimens and multiple carcinomas. a, The negative correlation of MAGI3 and c-Myc protein levels in clinical CRC specimens. Representative IHC staining of MAGI3 and c-Myc in 108 cases of CRC samples. Scale bars: 50 μm. Right panels are × 2 magnification of the dashed areas on the left. b, Pearson correlation analysis between MAGI3 and c-Myc in 108 cases of CRC samples. c, MAGI3 level negatively correlated with c-Myc activation in CRC patients. MAGI3 expression level was measured by RNA-Seq in 375 CRC samples from TCGA. Gene signature of c-Myc activation was defined as gene sets, DANG REGULATED BY MYC UP (the gene signature of c-Myc positive activation) and DANG REGULATED BY MYC DN (the gene signature of c-Myc negative activation) from the Molecular Signatures Database. The First Principal Component (PC1) of the c-Myc positive signature was negatively correlated with MAGI3 expression (left); while the PC1 of c-Myc negative signature was positively correlated with MAGI3 expression (right) (Pearson correlation). d, Enrichment plots of GSEA showed that the gene signatures of c-Myc positive activation were significantly enriched in low MAGI3 expression groups in esophageal squamous cell carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC) and thyroid carcinoma (THCA)

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