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Fig. 4 | Molecular Cancer

Fig. 4

From: A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML

Fig. 4

The truncated tnFGFR1 shows a distinct profile of oncogenic signaling compared with the full length chimeric kinases. RPPA analysis of BaF3 cells transduced with either empty vector (MIG) or tnFGFR1 and maintained on IL3, or transformed with the BCR-FGFR1 chimeric kinase or its GZMB site mutated version (A). Selected preferentially activated pathways identified by RPPA are further validated by western blotting (B)

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Molecular Cancer

ISSN: 1476-4598