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Fig. 5 | Molecular Cancer

Fig. 5

From: A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML

Fig. 5

tnFGFR1 regulates a specific subset of genes during leukemogenesis. RNA-Seq analysis of leukemic cells from the bone marrow from mice transplanted with stem cells transduced with either tnFGFR1 or the mutant BCR-FGFR1m (n = 2) construct identifies specific patterns of expressed genes as shown in the heat map in (A). GSEA analysis (B) identifies significant enrichment for differential changes in pathways involved in receptor signaling, actin and cytoskeleton, and molecular transduction. The comparison in expression changes of genes in related pathways using qPCR is shown in (C) and qPCR verification (N = 3) of several of the most highly differentially expressed genes is shown in (D)

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Molecular Cancer

ISSN: 1476-4598