Fig. 3From: Targeting KRAS mutant cancers: from druggable therapy to drug resistanceOverview of MAPK/PI3K signaling pathway and mechanisms of resistance to KRAS inhibitors. a Schematic representation of KRAS cycling and signaling pathway. b Mechanisms of resistance to KRAS inhibitors. Acquired mutations concerning the drug-binding sites and feedback activation of KRAS upstream and downstream signaling pathways favor drug resistance to KRAS mutant inhibitorsBack to article page