Fig. 1

Mutations in morphologically normal tissue: A From top to bottom: whether clonal expansions under positive selection were detected; sample type (morphologically normal tissue in prostate cancer patients, BPH tissue in prostate cancer patients, tissue from non-prostate cancer patients, BPH fibroblast cell culture); number of single nucleotide variants (SNVs) detected per sample; number of indels (insertions, deletions and complex insertions/deletions) per sample. Each column represents a sample and they are ordered according to sample type and decreasing number of SNVs. Eight rearrangements (not represented in figure) were detected across all patients (sample 0063_N (n = 1), 0127 (n = 3), 0073_N (n = 1), 0074_N (n = 1), 0006_N1 (n = 1) and sample 0006_N3 (n = 1)). A BRCA2 SNP (chr13:32,945,095) was detected in the blood of donor 0063. No copy number alterations were detected. B Plot showing the distribution of the number of SNVs found in BPH samples and non-BPH normal samples in prostate cancer patients; C the number of SNVs between normal samples from people with or without prostate cancer; D the number of indels between normal samples from people with or without prostate cancer