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Fig. 1 | Molecular Cancer

Fig. 1

From: The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

Fig. 1

miR-126-3p expression is silenced by hypermethylation of its promoter in lung cancer cells. A The miR-126-3p levels were measured by RT-qPCR in 67 pairs of lung adenocarcinoma tissues and adjacent non-tumor tissues. B RT-qPCR detected the miR-126-3p expression levels in BEAS-2B, A549, NCI-H1299, and H460 cells. C The overall survival of lung cancer patients with low or high miR-126-3p expression. D The relative expression levels of methylation of miR-126-3p were detected in tumor samples and adjacent lung samples by qRT-PCR. E MSP for methylation or demethylation of the miRNA-126-3p gene promoter in different LUAD and BEAS-2B cells. F The relative expression levels of miR-126-3p in different LUAD and BEAS-2B cells (treated with or without 5-Aza-dC for 24 h) were measured by RT-qPCR. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Molecular Cancer

ISSN: 1476-4598