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Fig. 2 | Molecular Cancer

Fig. 2

From: The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

Fig. 2

miR-126-3p is a negative regulator of ADAM9 in LUAD. A The target genes of miR-126-3p screened by mirDB database. B Diagram of putative miR-126-3p binding sequence in ADAM9 3′-UTR and its mutant in luciferase reporter assay. A luciferase reporter assay was performed to evaluate luciferase activity in A549 and NCI-H1299 cells. C ADAM9 mRNA levels were evaluated in lung adenocarcinoma tissues and adjacent lung tissues. D The correlation of miR-126-3p expression to mRNA expression in lung adenocarcinoma tissues. The mRNA (E) and protein (F) levels of ADAM9 in miR-126-3p mimic-transfected A549 and NCI-H1299 cells. The mRNA (G) and protein (H) levels of ADAM9 in A549 and NCI-H1299 cells treatment with 5-Aza, respectively. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Molecular Cancer

ISSN: 1476-4598