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Fig. 2 | Molecular Cancer

Fig. 2

From: Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Fig. 2

Monitoring classic tumor models with GLuc. a-c Monitoring of in vivo labelled transplanted lymphomas with GLuc. a Experimental scheme. Red color symbolizes GLuc activity. BLI, bioluminescence imaging. b Time course of GLuc activity in blood samples of mice transplanted with lymphoma cells from EµMyc;Rosa26GLuc/FLuc mice. Data points represent individual mice. c BLI of representative mice at different time points after mock or cyclophosphamide treatment. d-h Monitoring of non-transplanted (autochthonous) lung adenocarcinoma with GLuc. d Experimental scheme. e Temporal development of blood GLuc activity in mice of indicated genotype. f Longitudinal BLI of mice with indicated genotype. g Sequential MRI of the KrasLSL−G12D mouse. h H&E stain of the KrasLSL−G12D mouse lung at time of sacrifice All error bars indicate SD, all data points represent biological replicates/individual mice. BLI, bioluminescence imaging; MRI, magnetic resonance imaging; LUAD, lung adenocarcinoma

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Molecular Cancer

ISSN: 1476-4598