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Fig. 1 | Molecular Cancer

Fig. 1

From: m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

Fig. 1

Schematic diagram of the topic of this review. The tumour immune microenvironment (TIME) is characterized by hypoxia, metabolic reprogramming, acidity, and immune suppression. There is potential crosstalk between hypoxia and metabolic reprogramming (HIF signalling can induce tumour metabolic reprogramming, and altered metabolism affects oxygen consumption in tumours). Accumulated lactate generated by high aerobic glycolysis forms an acidic TIME. Hypoxia, metabolic reprogramming, and acidity promote immune suppression and lead to tumour immune evasion. This review provides an overview of m6A methylation patterns in the TIME and immune cells and the role of m6A methylation in tumour immune escape

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Molecular Cancer

ISSN: 1476-4598