Fig. 24From: PROTAC’ing oncoproteins: targeted protein degradation for cancer therapyCrystal structure of VCB-compound 98-Bcl-xL ternary complex (PDB 6ZHC). The PEGylated linker folds back after exiting the Bcl-xL binding pocket via the ethynyl exit vector. Image created using Schrödinger Bioluminate with PDB 6ZHC. VHL is depicted in cyan and Bcl-xL in brownish orangeBack to article page