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Fig. 7 | Molecular Cancer

Fig. 7

From: PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy

Fig. 7

Crystal structure of cIAP1Bir3–compound 33–BTKKD ternary complex (PDB 6W7O). The cIAP1 ligand of 33 forms a π-cation interaction with cIAP1R314 and hydrogen bonds with cIAP1 residues G312, R314, D320, E325, and W329. The linker carbonyl interacts with BTKC481 through hydrogen bonding. The BTK ligand forms hydrogen bonds with BTK residues E475 and M477 while the difluorophenyl group π–π stacks with BTKF540. Image created using Schrödinger Bioluminate with PDB 6W7O. BTKKD is depicted in cyan and cIAP1 in brownish orange

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