Fig. 1

High LH1 expression correlates with poor prognosis of HCC and PDAC patients A Heat map of the differentially expressed proteins between 8 paired HCC tissues and adjacent tissues via proteomic analysis. B GO molecular function analysis of the differentially expressed proteins. C Protein expression level of LH1 in HCC and adjacent tissues by the Western blot. D LH1 mRNA expression level in HCC tissues from TCGA database. E&F Kaplan–Meier survival analysis showing that patients with high LH1 expression level had shorter overall survival (OS) time in HCC (E), and PDAC (F) using KMplotter database. G&H Patients with high LH1 protein expression level had shorter OS time (G) and disease-free survival (DFS) time (H) in HCC patients (n = 132) by Kaplan–Meier survival analysis. I IHC staining showing the LH1 expression in HCC tumor embolus. J&K Patients with high LH1 protein expression level had shorter OS time (J) and DFS time (K) in PDAC patients (n = 43) via Kaplan–Meier survival analysis