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Fig. 2 | Molecular Cancer

Fig. 2

From: Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network

Fig. 2

LH1 overexpression promotes confined migration on multidimensional levels A Transwell migration of wild type (WT), control (Vector), and LH1-overexpressing SK-Hep1 and SNU449 cells. B Transwell migration of control (Vector) and LH1-overexpressing PANC1 cells. C Schematic view of the collective confined migration chip. D Schematic image of single cell confined migration chip. E–G 2D confined migration of wild type (WT), control (Vector), and LH1-overexpressing SK-Hep1 (E), SNU449 cells (F), and PANC1 cells (G). H 2D confined migration of control (Ctrl) and LH1-knockdown SW1990 cells. I Images showing the single cell confined migration in the chip of SNU449 cells. J Single cell confined migration percentage of LH1-overexpressing cells or LH1-knockdown cells. K-N Statistical results of 3D invasion of LH1-overexpressing SK-Hep1 (K), SNU449 (L), PANC1 (M), or LH1-knockdown PLC/PRF/5 cells (N). O The scanning electron microscope images of 60% or 95% substitutional GelMA with 40 s exposure. P 3D sphere formation of SK-Hep1 cells with or without LH1 overexpression. Q Knock down of LH1 suppressed the 3D invasion of PLC5 cells in stiff gels. *, P < 0.05;**, P < 0.01;***, P < 0.001

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