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Fig. 3 | Molecular Cancer

Fig. 3

From: Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network

Fig. 3

LH1 binds with SEPT2 and enhances actin polymerization A Venn diagram of the unique LH1-binding proteins in SK-Hep1 and Hela cells. B&C Co-immunoprecipitation and reverse immunoprecipitation showing the binding between LH1 and SEPT2 in different HCC cell lines (B) and PDAC cells (C). D FRET showing the interactions between LH1 and SEPT2 among HCC and PDAC cell lines. E&F Immunofluorescence showing F-actin in LH1-overexpressing SK-Hep1 (E) and SNU449 (F) cells. G Immunofluorescence showing F-actin in LH1-knockdown SW1990 (upper panel) and PLC/PRF/5 (lower panel) cells. H Representative FRAP images at indicated time points of LH1-overexpressing or control SNU449 cells. I-K Statistical results of FRAP assays in SNU449 (I), SK-Hep1(J), and SW1990 (K) cells

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Molecular Cancer

ISSN: 1476-4598