Skip to main content
Fig. 3 | Molecular Cancer

Fig. 3

From: Cuproptosis: mechanisms and links with cancers

Fig. 3

Copper and cancer singnaling pathways. Copper is strongly associated with the process of cancer and impacts them in a direct or indirect ways. Copper directly binds or activates EGFR, PDK1 or PI3K to promotes tumorigenesis. Copper also influences MAPK and autophagic pathways or indirectly changes c-Myc stability to influence tumor growth. Copper ions indirectly promotes HIFα or indirectly inhibits the Notch pathway ligand Jagged1 thus promoting vascular neoplastic migration. In addition, copper can also regulate PDE3B or S6K1 and thus modulates tumor metabolism

Back to article page