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Table 1 Hematological processes regulated by the mammalian SWI/SNF complex

From: SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities

Subunit

Biological process

Refs.

ACTL6A

Maintenance of hematopoietic stem cells (HSCs)

[54]

ARID1A

Maintenance of HSCs and differentiation of both myeloid and lymphoid lineages

[55]

T cell development

[59]

ARID1B

Erythropoiesis

[68]

ARID2

Maintenance of HSCs and erythropoiesis

[37]

Regeneration of lymphoid lineage

[35]

BCL11A

B-cell and T-cell development

[71]

Regulation of ɣ-globin gene

[72,73,74,75]

Maintenance of HSCs

[76]

BCL11B

Thymocyte differentiation

[77]

BRD9

Functional modulation of Regulatory T (T-reg) cells

[78]

PBRM1

Maintenance of HSCs

[56]

PHF10

Maintenance of HSCs and myeloid lineage development

[57]

SMARCA2

Regulatory function in HSCs and HPCs (hematopoietic progenitor cells)

[58]

SMARCA4

Erythroid development

[60,61,62]

Granulocytic maturation

[63]

T-cell differentiation

[64,65,66]

Development of pro-B cells

[67]

Formation and maintenance of HPCs

[79]

Myeloid lineage differentiation

[80]

SMARCC1

Development of pro-B cells

[67]

Thymocyte maturation

[81]

SMARCD2

Granulocytic maturation

[69, 70]

SMARCE1

T-cell differentiation

[64]