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Table 2 SWI/SNF role in hematological tumors

From: SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities

 

Subunit

Role (TS/OG/TM)a

Malignancy

Described effect

Refs.

ATPase-Helicase

SMARCA4

TM

AML

Maintenance of leukemic cells

[51, 85, 87]

SMARCA2/4

TM

AML

Higher dependency on SMARCA4 and SMARCA2 in leukemic cells

[88]

ARID subunits

ARID1A

TM

AML

Maintenance of leukemic cells

[51]

TS

AML

Its loss increases cell proliferation and inhibits apoptosis of AML cells

[89]

ARID1B

TS

AML

Its loss accelerates leukemogenesis and promotes leukemic maintenance

[36]

TS

APL

Required for cellular differentiation

[84]

ARID2

TS

AML

Its loss accelerates leukemogenesis

[36, 37]

TM

AML

Maintenance of leukemic cells

[36]

Core subunits

SMARCB1

TS

Its loss promotes lymphomagenesis (CD8+ T cells)

[90]

TS

CML

Its loss accelerates leukemogenesis

[91]

TS

AML

Its loss activates oncogenic gene expression programs

[92]

SMARCC1

TM

AML

Maintenance of leukemic cells

[51]

SMARCD1

TM

AML

Maintenance of leukemic cells

[51]

SMARCD2

TM

AML

Maintenance of leukemic cells

[51, 85]

Accessory subunits

ACTL6A

TM

AML

Maintenance of leukemic cells

[51]

BCL7A

TS

DLBCL

Impairs proliferation of DLBCL cells

[86]

BCL11A

OG

CLL, NHL, and HL

Chromosomal translocations or amplifications of this gene are found in lymphoid malignancies

[93]

OG

AML

Acceleration of the onset of Trib1-induced AML. Its loss reduces leukemogenicity

[94]

OG

Increases the onset of leukemia of either myeloid or lymphoid lineage

[95]

TM

NKTL

Its loss increases apoptosis and reduces proliferation of NKTL cells

[96]

BCL11B

TS

CML

Haploinsufficiency of Bcl11b promotes oncogenicity of the Bcr-Abl fusion in CML

[97]

TS

T-ALL

Haploinsufficient tumor suppressor

[98]

OG

ALAL

Cell self-renewal, myeloid differentiation blockage, activation of T cell genes

[99, 100]

DPF2

TM

AML

Maintenance of leukemic cells

[85]

BRD9

TM

ALL, MM

Its loss promotes apoptosis and sensitizes ALL and MM cells to chemotherapy.

[101]

TM

AML

Maintenance of leukemic cells

[102]

  1. aTS Tumor suppressor, OG Oncogene, TM Tumor-Maintenance, ALAL acute leukemia of ambiguous lineage, ALL acute lymphoblastic leukemia, AML acute myeloid leukaemia, APL acute promyelocytic leukaemia, CLL chronic lymphocytic leukemia, CML chronic myeloid leukaemia, DLBCL diffuse large B cell lymphoma, HL Hodgkin lymphoma, MM multiple myeloma, NKTL natural killer T cell lymphoma, NHL non-hodgkin lymphoma; -: unclassified