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Fig. 4 | Molecular Cancer

Fig. 4

From: TGF-β signaling promotes cervical cancer metastasis via CDR1as

Fig. 4

CDR1as promoted EMT in cervical cancer cells via binding with IGF2BP1. A qPCR was performed after pull-down using CDR1as probe; B Silver staining was performed after pull-down using CDR1as probe, a distinct band was discovered at 70 kD; C Western blot assay was performed after pull-down using CDR1as probe; D RIP assay using anti-IGF2BP1 shows an obvious enrichment of CDR1as; E qPCR was performed after IGF2BP1 was silenced; F, G,Primers were designed for Slug’s M6A modification site, RIP assay using anti-m6A and anti- IGF2BP1 showed evident enrichment of Slug; I inhibition of IGF2BP1 reduced CDR1as-promoted metastatic and invasive potential

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