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Fig. 2 | Molecular Cancer

Fig. 2

From: Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Fig. 2

ECM role in proliferation, cell cycle arrest and anoikis resistance. The changes in ECM proteins, especially the crosslink of collagen, enhance the stiffness of ECM. Receptors sense the mechanic signal form ECM and activates downstream pathways including FAK and YAP/TAZ to induce cell cycle progression and cell-ECM adhesion (A). Moreover, ECM support detachment cell survival, even induce cell cycle arrest in a quiescent state to decrease energy consumption and resist to anoikis (B). Several components support the acquirement of anoikis resistance such as tenascin-C, collagen, HA and PDGFB (C)

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Molecular Cancer

ISSN: 1476-4598