Table 1 Role of other ECM proteins in tumor progression

Pancreatic cancer

Fibronectin

Fibronectin determines SPARC function to control proliferation and anti-apoptosis

[212]

Prostate cancer

Plectin

Plectin Knock-down impairs cell growth and metastasis

[213]

Breast cancer

FGF2

FGF2 promotes ER/Cyclin D1 signaling and endocrinotherapy resistance

[214]

Fibulins

Estradiol indued fibulin-1 inhibits fibronectin induced motility of cancer

[215]

Glioblastoma

Collagen I and fibronectin

3D culture model stimulates tumor progression via PI3K and CDC42 pathway

[216]

Fibulin-3

Inhibition of fibulin-3 suppresses activation of ADAM17/Notch/NK-κB pathway and tumor progression

[217]

Hepatoma

Periostin

Autocrine loop of periostin/integin/FAK/STAT3/perison in hepatic stellate cell promotes hepatoma cell proliferation via paracrine stimuli

[218]

Epimorphin

Cancer secretes epimorphin promotes malignant invasion and metastasis

[219]

Laminin-332

Laminin 332 antibody targeting matrix binding domain suppress tumor progression

[220]

Laminin 332 sustains stem state and chemoresistance via phosphorylating mTOR

[221]

Colorectal cancer

MGP

MGP expression favors oxaliplatin resistance

[222]

Periostin

Interaction loop between fibroblast secreted periostin and cancer derived IL-6 contributes to the progression of colitis-associated colorectal cancer

[223]

Fibulins

Fibulin-5 inhibits TRPV1 to induce cell apoptosis via ROS/MAPK and Akt pathways

[224]

Fibrinogen

Fibrinogen actives FAK to suppress P53 and sustain cell proliferation and anti-apoptosis

[225]

HAPLN1

HAPLN1 against TGF-β-induced COL1A1 expression and ECM remodeling

[226]

Gastric cancer

ECM1

ECM1 stimulate ITGB4/FAK/SOX2/HIF-1α to promote metastasis and glucose metabolism

[227]

Lumican

CAFs derived Lumican induces tumor progression via β1-FAK pathway

[228]

Non-small cell lung cancer

Fibulins

Methylated FBLN2 inhibits tumor proliferation and cell adhesion via MAPK/ERK and AKT/mTOR pathways

[229]

Hyaluronan

Hyaluronan-CD44/RHAMM mediates cell proliferation and anti-apoptosis

[104]

Laminin

Laminin 5/integrin/FAK stimulates EGFR activation to promote anoikis resistance and invasion

[230]

Myeloma

Reelin

Reelin promotes cell proliferation and glycolysis via FAK/Syk/Akt/mTOR and STAT3 pathways

[231]

Fibronectin

In vitro Coculture of cancer cell and fibronectin enhances MMP9 expression and MMP2 activation

[232]

Ovarian cancer

COL11A1

COL11A1-DDR2 stimulates Src-PI3K/Akt/NF-κB signaling to induce cisplatin resistance

[233]

Chondrosarcoma

OPN

Osteopontin stimulates MMP-9 expression via β3 integrin/FAK pathway to induce migration

[234]

Cutaneous squamous carcinoma

Fibulins

Fibulin-3 inhibits Akt signaling pathway and suppresses tumor progression

[235]

Cervical cancer

MFAP5

MFAP5 inhibition triggers cell cycle arrest and apoptosis

[236]