Fig. 1
From: Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy
Mechanisms of RNA m6A modification. The adenosine (A) in mRNA is methylated to form N6-methyladenosine (m6A) via the core subunit of the methyltransferase complex (MTC) constitute by METTL3-METTL14-WTAP, and other writers, such as METTL5, METTL16, VIRMA, ZCCHC4, ZC3H13, CBLL1, RBM15 and RBM15B. m6A can be removed by erasers, including FTO, ALKBH3 and ALKBH5. The biological roles of m6A in RNA metabolism are exerted by readers, including YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, and HNRNPC/HNRNPG/HNRNPA2B1