Fig. 4
From: Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy
Therapeutic strategies targeting m6A modification. A. Targeting m6A regulators by ncRNAs, including miRNAs, lncRNAs, circRNAs, siRNAs and shRNAs to orchestrate the expression of m6A regulators. B. Nanoparticles (NPs), such as OsSx-PEG, GNRa-CSP12 and GNPIPP12MA, manipulate m6A modification in distinct manners; nanoparticles have also been developed to encapsulate drugs, siRNAs and circRNAs to regulate m6A modification. C. CRISPR‒Cas-based gene editing technologies for site-specific m6A methylation. D. Small-molecules targeting m6A regulators