Table 2 CSCs targeted CAR-T cells therapy in clinical trials
Trial | Solid Tumor | Phase | Enrollment | NCT Number | Current status |
|---|---|---|---|---|---|
CD133 CAR-T | Advanced malignancies | I/II | 20 | NCT02541370 | Completed |
MUC1 CAR-T/PD-1 KO | Advanced esophageal cancer | I/II | 20 | NCT03706326 | Recruiting |
EGFR IL-12 CAR-T | Metastatic colorectal cancer | I | 20 | NCT03542799 | Not yet recruiting |
MESO CAR-T | Refractory–relapsed ovarian cancer | I/II | 20 | NCT03916679 | Recruiting |
MESO-19 CAR-T | Metastatic pancreatic cancer | I | 4 | NCT02465983 | Completed |
MOv19-BBz CAR -T | Recurrent high-grade serous ovarian cancer | I | 18 | NCT03585764 | Recruiting |
LeY CAR-T | Advanced cancer | I | 30 | NCT03851146 | Recruiting |
EpCAM CAR-T | Recurrent breast cancer | I | 30 | NCT02915445 | Recruiting |