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Fig. 3 | Molecular Cancer

Fig. 3

From: The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers

Fig. 3

The epigenetic regulatory mechanism of PIWI/piRNAs on human cancers. A PIWI proteins regulate gene expression in cancer in a piRNA independent manner, mainly through binding with other functional proteins (such as methyltransferase, ubiquitination enzyme, phosphorylase, etc.); B PIWI proteins regulate gene expression in cancer in a piRNA dependent manner, which is similar to that in normal cells; C piRNAs independently regulate mechanisms in cancer, exerting epigenetic regulatory functions by binding with epigenetic regulatory factors or directly regulating their expression. piRNAs can also bind with target gene to degrade mRNA, change its mRNA stability, or inhibit its translation process

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