New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

Table 1 B7 family proteins and their binding partners

B7 family ligands	Alternative names	Receptor (binding) partners	Effect of ligand-receptor interaction	References
B7-1	CD80	CD28, CTLA-4, PD-L1	Co-stimulatory or Co-inhibitory	https://doi.org/10.1073/pnas.0507257102
B7-2	CD86	CD28, CTLA-4	Co-stimulatory or Co-inhibitory	https://doi.org/10.1073/pnas.0507257102
B7-DC	PD-L2, CD273	??, PD-1	Co-stimulatory or Co-inhibitory	https://doi.org/10.1084/jem.20050072
B7-H1	PD-L1, CD274	??, PD-1	Co-stimulatory or Co-inhibitory	https://doi.org/10.1038/70932, https://doi.org/10.1016/j.hemonc.2013.09.005
B7-H2	B7RP1, CD275	ICOS	Co-stimulatory	PMID: 21,530,327
B7-H3	CD276	??	Co-stimulatory or Co-inhibitory	https://doi.org/10.1038/85339, https://doi.org/10.1038/ni967,
B7-H4	VTCN1, B7x, B7S1	??, BTLA	Co-stimulatory or Co-inhibitory	https://doi.org/10.1016/S1074-7613(03)00152-3
B7-H5	VISTA, Platelet receptor Gi24, SISP1	??	Co-inhibitory	https://doi.org/10.1084/jem.20100619
B7-H6	NCR3LG1	NKp30	Co-stimulatory effect for NK cells	https://doi.org/10.1007/s00251-012-0616-2
B7-H7	HHLA2	CD28H	Co-stimulatory or Co-inhibitory	https://doi.org/10.1073/pnas.1303524110

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