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Fig. 1 | Molecular Cancer

Fig. 1

From: Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis

Fig. 1

Cuproptosis-related gene expression differences, genetic variation, and drug sensitivity analysis. A Differential expression of CRG. The blue dots indicate low gene expression in the tumor and the red dots represent high gene expression in tumors. B SNV oncoplot. The cancer map shows the distribution of the classification of SNV types (e.g., missense mutations, frame-shift loss, and nonsense mutations) in CRG. Selected cancer samples are shown together on one side and a bar diagram at the top shows the number of mutations in each sample or gene. C CNV pie distribution in 33 cancers. A pie represented the proportion of different types of CNV of one gene in one cancer, and different colors represented different types of CNV. Hete Amp, heterozygous amplification; Hete Del, heterozygous deletion; Homo Amp, homozygous amplification; Homo Del, homozygous deletion; None, no CNV. D Methylation difference of CRG in each cancer. The red dots indicate high methylation in cancers, while the blue dots mean low methylation. The solid circles represent FDR < 0.05, a significant correlation. E Correlation between GDSC drug sensitivity and mRNA expression. Blue represents a negative correlation, suggesting higher the gene expression, the lower the drug amount required, and the higher the sensitivity. F, G Immunohistochemical staining results of DLD of lung squamous carcinoma tissue. H Statistical results of DLD expression in lung squamous carcinoma and paraneoplastic tissues

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