Fig. 2From: CAR T-Cell therapy for the management of mantle cell lymphomaDifferent generations of CARs and manufacturing process of Tisagenlecleucel CAR. A. Generations of CAR. All the approved CARs are from the second generation. B. manufacturing process of Tisagenlecleucel CAR Abbreviations: scFv; variable fragments of a single-chain antibody, TM; transmembrane protein, CoStim; Costimulatory domain, IL; Interleukin Back to article page