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Fig. 9 | Molecular Cancer

Fig. 9

From: Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Fig. 9

CircCCAR1 promotes the resistance of HCC to anti-PD1 therapy. A Exosomal circCCAR1 levels in the serum from HuNSG mice. ***p < 0.001. B CD8-positive cells in HCCLM3-circCCAR1 or HCCLM3-mock cell-derived xenografts were detected by CD8 staining. C-E The tumor volume and weight. F The survival curves for mice with xenografts. G CD8 in tissues from HCC patients was analyzed by CD8 staining. ***p < 0.001. H The relationship between circCCAR1 and infiltrated CD8-positive cells in the HCC tissues was calculated. I The relationship between exosomal circCCAR1 in serum and CD8-positive cell numbers in HCC tissues was also calculated. J Model of the circCCAR1-mediated immunosuppressive effect in HCC

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Molecular Cancer

ISSN: 1476-4598