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Fig. 2 | Molecular Cancer

Fig. 2

From: HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

Fig. 2

HOTAIR inhibits tumor suppressor miRNAs and activates pro-oncogenic miRNAs in BC. Activation of oncogenic miRNAs enhances the expression of EMT-specific proteins involved in metastasis by activating HOTAIR expression. HOTAIR regulates the miR-129-5p/FZD7 axis, which promotes EMT via the regulation of E-cadherin and N-cadherin vimentin. HOTAIR also activates the miR601/ZEB1 axis, which promotes metastasis by activating AKT. HOTAIR promotes angiogenesis by inducing the transcription of VEGF via direct interaction at the promoter or the activation of the GRP78/Ang2 axis

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