Fig. 4
From: HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
HOTAIR is overexpressed in trastuzumab-resistant BC cells and upregulates the expression of EMT-related proteins SNAIL, TGFß, and vimentin. At the same time, it also upregulates PTEN gene promoter methylation and downregulates TGFß gene promoter methylation. The siRNA-mediated silencing of HOTAIR in DOX-resistant BC cells downregulates the expression of oncogenic and anti-apoptotic proteins MDR1, MRP1, ABCB1, and Bcl2 and upregulates the pro-apoptotic proteins caspase 3 and Bax