Table 2 Overview of deregulated circRNAs in renal cell carcinoma
From: The function and mechanisms of action of circular RNAs in Urologic Cancer
CircRNA | Expression | Function | Target microRNA | miRNA target genes/protein | Ref |
|---|---|---|---|---|---|
Circ000926 | Up | Proliferation(+) Metastasis(+) | miR-411 | CDH2 | [106] |
CircEGLN3 | Up | Proliferation(+) Metastasis(+) | miR-1224-3p | HMGXB3 | [107] |
CircRAPGEF5 | Down | Proliferation(-) Metastasis(-) | miR-27a-3p | TXNIP | [115] |
Circ0001368 | Down | Proliferation(-) Metastasis(-) | miR-492 | LATS2 | [116] |
Circ0054537 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR- 130a-3p | cMet | [122] |
CircSCARB1 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR-510-5p | SDC3 | [108] |
CircUBAP2 | Down | Proliferation(-) Metastasis(-) | miR-148a-3p | FOXK2 | [117] |
CircMTO1 | Down | Proliferation(-) Metastasis(-) | miR-9 | LMX1A | [109] |
CircAKT3 | Down | Metastasis(-) | miR-296-3p | E-cadherin | [118] |
CircTLK1 | Up | Proliferation(+) Metastasis(+) | miR-136-5p | CBX4 | [110] |
CircSDHC | Up | Proliferation(+) Metastasis(+) | miR-127-3p | CDKN3/E2F1 | [111] |
CircCHST15 | Up | Proliferation(+) Metastasis(+) | miR-125a-5p | EIF4EBP1 | [112] |
CircESRP1 | Down | Proliferation(-) Metastasis(-) | miR-3942 | CTCF | [119] |
Circ0005875 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR-502-5p | ETS1 | [123] |
Circ0035483 | Up | Proliferation(+) Metastasis(+) | miR-31-5p | HMGA1 | [127] |
CircDVL1 | Down | Proliferation(-) Metastasis(-) Apoptosis(+) | miR-412-3p | PCDH7 | [113] |
CircEGLN3 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR-1299 | IRF7 | [124] |
CircMYLK | Up | Proliferation(+) Metastasis(+) | miR-513a-5p | VEGFC | [120] |
Circ001842 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR-502-5p | SLC39A14 | [125] |
CircNUP98 | Up | Proliferation(+) Metastasis(+) Apoptosis(−) | miR-567 | PRDX3 | [126] |
CircFOXP1 | Up | Proliferation(+) Metastasis(+) | miR-423-5p | U2AF2 | [128] |
CircPSD3 | Down | Proliferation(-) Metastasis(-) | miR-25-3p | FBXW7 | [114] |
CircTXNDC11 | Up | Metastasis(+) | - | MAPK/ERK | [121] |
Circ0054537 | UP | Glycolysis(+) Apoptosis(−) | miR-640 | NPTX2 | [129] |