Fig. 1

The Super enhancers landscape of primary NKTL patient samples, NKTL cell lines and the controls. A Enhancer regions of in 3 primary NKTL patients. Enhancers were ranked by increasing H3K27Ac signal, and enhancers above the inflection point of the curve were defined as SEs, and the number of SEs was shown for each sample. Examples of SEs associated genes found in at least two primary MM cases were also presented. B Schematic diagram of the selection criteria for high-confident candidate SE-associated genes. C The list of final 191 SE-associated genes selected according to the criteria shown in (B) was classified into different function group. D NKTL-SE genes were enriched in multiple signaling pathways related to NK cell function. E Track view of H3K27ac ChIP-seq density profile centered at the TOX2 gene loci of NKTL cell line HNAK1 and NKYS (top panel), 3 tonsil controls (middle panel) and 3 primary NKTL patient samples (lower panel). Locations of the SEs regions were marked by black bars