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Fig. 1 | Molecular Cancer

Fig. 1

From: Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

Fig. 1

The anatomic and genomic distribution of GIST. A The anatomic locations of primary and metastatic GISTs. Primary GISTs usually originate from stomach and small intestine, and metastasize to liver or peritoneum. B The genomic profiles of GISTs. KIT and PDGFRA signaling are activated by their natural ligands SCF and PDGF respectively in physiological conditions, but are constitutively activated by oncogenic mutations and in a ligand independent manner in GISTs. According to the driver mutations, GISTs can be broadly classified as KIT-mutant GISTs, PDGFRA-mutant GISTs and KIT/PDGFRA-WT GISTs, and the last one could be further divided into SDH-deficient and SDH-competent GISTs based on the expression of succinate dehydrogenase. GIST: gastrointestinal stromal tumor; PDGFRA: platelet-derived growth factor receptor alpha; WT: wild type; EC: ligand-binding extracellular domain; TM: transmembrane domain; JM: intracellular juxtamembrane domain; TK: tyrosine kinase domain; SDH: succinate dehydrogenase; SCF: stem cell factor; PDGF: platelet-derived growth factor

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