Fig. 2
From: Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers
The immune microenvironment of GIST. A GIST is mainly infiltrated with T cells and M2 macrophages, and less frequently by NK, B and DC cells. Approximately half of the GISTs harbor intratumoral tertiary lymphoid structures which were enriched with T cells and B cells. B Gross comparisons of the immune cell infiltration between different groups. Immune cells seem to be enriched in metastatic GIST (especially liver metastasis), non-gastric GIST and PDGFRA-mutant GIST and the margin area of the GIST. GIST: Gastrointestinal stromal tumor; NK: natural killer cell; MΦ: macrophages; M1: M1 that macrophages are classically activated; M2: M2 macrophages that are alternatively activated; DC: dendritic cell; Th1: T helper type 1 cell; Th2: T helper type 2 cell; γδ T cell: gamma delta T cell with T cell receptors (TCRs) composed of γ- and δ-chains