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Table 1 Systemic inflammatory indicators in GIST

From: Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

Author & Year

Regions

No. of patients

Sample

Tested items

Prognosis

Associated clinicopathological parameters

Ref

Perez et al. 2013

USA

339

Preoperative

NLR

RFS (-)

Tumor size, mitotic index

[42]

Jin et al. 2013

China

42

Preoperative

NLR

OS (-)

Tumor size, mitotic index

[43]

Atila et al. 2014

Turkey

67

Preoperative

NLR

DFS (-)

NA

[44]

Kargın et al. 2015

Turkey

78

Preoperative

NLR

OS (-)

Mitotic index

[45]

Racz et al. 2015

Canada

93

Preoperative

PLR, neutrophils

RFS (-)

Tumor size, mitotic index

[39]

Goh et al. 2016

Singapore

300

Preoperative

NLR, PLR

RFS (-)

NIH risk, AFIP risk

[46]

Stotz et al. 2016

Austria

149

Preoperative

PLR

RFS (-)

NA

[47]

Jiang et al. 2016

China

129

Preoperative

NLR

OS (-)

Tumor stage

[48]

Feng et al. 2016

China

274

Preoperative

NLR, MLR, PLR, NWR, MWR, low LWR

RFS (-)

Tumor size and location, mitotic index, NIH risk

[49]

Yin et al. 2017

China

400

Preoperative

PLR

RFS (-)

Tumor size, mitotic index, NIH risk

[50]

Xue et al. 2017

China

510

Preoperative

NLR

RFS (-)

NA

[51]

Luo et al. 2018

Meta

1676

Unclear

NLR

DFS (-), RFS (-)

Tumor size, mitotic index, NIH risk

[52]

Hu et al. 2018

China

92

Preoperative

PLR

RFS (-)

Mitotic index

[53]

Rutkowski et al. 2018

Poland

385

Imatinib treated

NLR

OS (-), RFS (-)

Mitotic index, driver mutation

[54]

Liu et al. 2018

Meta

1735

Preoperative

PLR

DFS (-), RFS (-)

Tumor size, mitotic index, NIH risk

[55]

Zhang et al. 2019

Meta

2264

Unclear

NLR

DFS (-), RFS (-)

Not mentioned

[56]

Yilmaz et al. 2019

Turkey

45

Unclear

NLR

OS (-)

NA

[57]

Sun et al. 2019

China

431

Preoperative

NLR, PLR

RFS (-)

NA

[58]

Sobczuk et al. 2019

Poland

146

Preoperative

NLR

OS (-)

Not associated

[59]

Yang et al. 2019

China

72

Preoperative

NLR

OS ( +)

Tumor size and location, age

[60]

Cananzi et al. 2019

Italy

127

Preoperative

MLR, NLR, PLR

DFS (-)

NA

[38]

Shi et al. 2019

China

340

Preoperative

PNI

RFS ( +)

NIH risk

[61]

Sun et al. 2020

China

85

Preoperative

NLR

PFS (-), OS (-)

NA

[62]

Wei et al. 2020

Meta

3135

Unclear

NLR, PLR

DFS (-)

Tumor size, tumor stages, mitotic index

[63]

Catal et al. 2020

Turkey

30

Preoperative

LMR

NA

AFIP risk score

[64]

Lin et al. 2020

China

424

Preoperative

PLR

RFS (-)

Not associated

[65]

Li et al. 2020

China

229

Unclear

NAR

RFS (-)

Not associated

[66]

Chang et al. 2020

China

646

Preoperative

PLR

DFS (-), OS (-)

Tumor size and location, NIH risk

[67]

Guo et al. 2020

China

143

Preoperative

Lymphocyte

DFS ( +)

No significant association

[68]

Yan et al. 2021

China

843

Preoperative

NLR, WLR, MLR, PLR

NA

NIH risk

[69]

Li et al. 2021

China

392

Preoperative

PNI

RFS ( +)

NA

[70]

Lu et al. 2021

China

160

Preoperative

SII

RFS (-)

NA

[71]

Zhao et al. 2022

China

591

Preoperative

HALP

RFS ( +)

Tumor size, site, NIH risk, mitotic index

[72]

Li et al. 2022

Meta

2627

Preoperative

PNI

RFS ( +)

NA

[73]

Yang et al. 2022

China

455

Preoperative

CONUT

RFS (-)

Tumor size and location

[74]

Ding et al. 2023

China

57

Preoperative

SII-PNI

RFS (-)

NA

[75]

  1. Abbreviations DFS Disease-free survival, RFS Recurrence-free survival, OS Overall survival, PFS Progression free survival, PLR Platelet-to-lymphocyte ratio, NLR Neutrophil-to-lymphocyte ratio, MLR Monocyte-to-lymphocyte ratio, NWR Neutrophil-to-white blood cell ratio, LWR Lymphocyte-to-white cell ratio, MWR Monocyte-to-white cell ratio, PWR Platelet-to-white cell ratio, NAR Neutrophil-to-albumin ratio, LMR Lymphocyte-to-monocyte ratio, AFIP Armed Forces Institute of Pathology, HALP The combined index of hemoglobin, albumin, lymphocyte, and platelet, PNI Prognostic nutritional index (albumin plus lymphocytes), SII Systemic immunoinflammatory index (platelet count × neutrophil count/lymphocyte count), CONUT Controlling nutritional status calculated from albumin, lymphocyte count and cholesterol, SII-PNI SII combined with PNI scores. + , positive correlation; -, negative correlation