Fig. 4
Molecular mimicry of MAGE-A1 and microbiota peptides. The MAGE-A1278 − 286 KVLEYVIKV peptide and the homologous peptides derived from the indicated microbiota bacteria are shown bound to the HLA-A*02:01 molecule. (A) The TCR facing residues are presented to the TCR αβ chains with the same conformation. (B) The contact areas in red between the peptides and the TCR αβ chains are mostly identical. (C) The areas of contact between the HLA molecule and the TCR αβ chains are identical (yellow and dark blue areas). (D) CD8+ T cells from a HCC patient (HCC) and a healthy donor (HD) were incubated with the MAGE-A1278 − 286 KVLEYVIKV peptide and the indicated homologous peptides derived from microbiota bacteria. Values represent the level of CD8+ T cell activation expressed as absolute value of fold-increase