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Molecular Cancer

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  1. Content type: Research

    Chromodomain-helicase DNA binding protein 5 (CHD5) is an important tumor suppressor gene deleted from 1p36.31 in neuroblastomas (NBs). High CHD5 expression is associated with a favorable prognosis, but deletio...

    Authors: Mayumi Higashi, Venkatadri Kolla, Radhika Iyer, Koumudi Naraparaju, Tiangang Zhuang, Sriharsha Kolla and Garrett M. Brodeur

    Citation: Molecular Cancer 2015 14:150

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  2. Content type: Research

    The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung meta...

    Authors: María Contador-Troca, Alberto Alvarez-Barrientos, Jaime M. Merino, Antonio Morales-Hernández, María I. Rodríguez, Javier Rey-Barroso, Eva Barrasa, María I. Cerezo-Guisado, Inmaculada Catalina-Fernández, Javier Sáenz-Santamaría, Francisco J. Oliver and Pedro M. Fernandez-Salguero

    Citation: Molecular Cancer 2015 14:148

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  3. Content type: Review

    The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success ...

    Authors: Antonio Palumbo Jr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto and Luiz Eurico Nasciutti

    Citation: Molecular Cancer 2015 14:145

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  4. Content type: Research

    Combined treatment of oncolytic adenoviruses with chemotherapeutic agents is foreseen as a therapeutic option for cancer. Here we have investigated the potential to use gemcitabine in combination with the onco...

    Authors: Maria Victoria Maliandi, Ana Mato-Berciano, Luciano Sobrevals, Gaël Roué, Anabel José and Cristina Fillat

    Citation: Molecular Cancer 2015 14:146

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  5. Content type: Research

    Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screeni...

    Authors: Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth and Ralph Minter

    Citation: Molecular Cancer 2015 14:147

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  6. Content type: Erratum

    Authors: Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis…

    Citation: Molecular Cancer 2015 14:144

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    The original article was published in Molecular Cancer 2015 14:94

  7. Content type: Research

    Dystroglycan (DG) is a cell-surface laminin receptor that links the cytoskeleton to the extracellular matrix in a variety of epithelial tissues. Its function as a matrix receptor requires extensive glycosylati...

    Authors: Michael R. Miller, Deqin Ma, James Schappet, Patrick Breheny, Sarah L. Mott, Nadine Bannick, Eric Askeland, James Brown and Michael D. Henry

    Citation: Molecular Cancer 2015 14:141

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  8. Content type: Research

    Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown that the hypoxia-inducible cellular oxygen sensor ...

    Authors: Heidi Högel, Petra Miikkulainen, Lucia Bino and Panu M. Jaakkola

    Citation: Molecular Cancer 2015 14:143

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  9. Content type: Short communication

    Adenocarcinoma in situ (AIS) of the lung has an extremely favorable prognosis. However, early but invasive adenocarcinoma (eIA) sometimes has a fatal outcome. We had previously compared the expression profiles...

    Authors: Aya Shiba-Ishii, Yunjung Kim, Toshihiro Shiozawa, Shinji Iyama, Kaishi Satomi, Junko Kano, Shingo Sakashita, Yukio Morishita and Masayuki Noguchi

    Citation: Molecular Cancer 2015 14:142

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  10. Content type: Research

    The epidermal growth factor (EGF) family of ligands has been implicated in promoting breast cancer initiation, growth and progression. The contributions of EGF family ligands and their receptors to breast canc...

    Authors: Mariya Farooqui, Laura R. Bohrer, Nicholas J. Brady, Pavlina Chuntova, Sarah E. Kemp, C. Taylor Wardwell, Andrew C. Nelson and Kathryn L. Schwertfeger

    Citation: Molecular Cancer 2015 14:138

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  11. Content type: Research

    Characterization of molecular mechanisms underpinning development of pancreatic ductal adenocarcinoma (PDAC) may lead to the identification of novel therapeutic targets and biomarkers. SgK223, also known as Pr...

    Authors: Carole M. Tactacan, Yu Wei Phua, Ling Liu, Luxi Zhang, Emily S. Humphrey, Mark Cowley, Mark Pinese, Andrew V. Biankin and Roger J. Daly

    Citation: Molecular Cancer 2015 14:139

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  12. Content type: Research

    An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In t...

    Authors: Ni Chen, Meiping Ren, Rong Li, Xin Deng, Yongjie Li, Kai Yan, Lamei Xiao, Yan Yang, Liqun Wang, Mao Luo, William P. Fay and Jianbo Wu

    Citation: Molecular Cancer 2015 14:140

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  13. Content type: Research

    Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is a...

    Authors: Ling Ling, Si Kee Tan, Ting Hwee Goh, Edwin Cheung, Victor Nurcombe, Andre J. van Wijnen and Simon M. Cool

    Citation: Molecular Cancer 2015 14:136

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  14. Content type: Research

    Urinary bladder cancer is one of the most fatal and expensive diseases of industrialized world. Despite the strenuous efforts, no seminal advances have been achieved for its clinical management. Given the impo...

    Authors: Eumorphia G. Konstantakou, Gerassimos E. Voutsinas, Athanassios D. Velentzas, Aggeliki-Stefania Basogianni, Efthimios Paronis, Evangelos Balafas, Nikolaos Kostomitsopoulos, Konstantinos N. Syrigos, Ema Anastasiadou and Dimitrios J. Stravopodis

    Citation: Molecular Cancer 2015 14:135

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  15. Content type: Short communication

    Glioblastoma (GBM) is the most frequent and aggressive type of adult brain tumor. Most GBMs express telomerase; a high level of intra-tumoral telomerase activity (TA) is predictive of poor prognosis. Thus, tel...

    Authors: Sylvain Ferrandon, Céline Malleval, Badia El Hamdani, Priscillia Battiston-Montagne, Radu Bolbos, Jean-Baptiste Langlois, Patrick Manas, Sergei M Gryaznov, Gersende Alphonse, Jérôme Honnorat, Claire Rodriguez-Lafrasse and Delphine Poncet

    Citation: Molecular Cancer 2015 14:134

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  16. Content type: Research

    Docosahexaenoic acid (DHA) is a natural compound with anticancer and anti-angiogenesis activity that is currently under investigation as both a preventative agent and an adjuvant to breast cancer therapy. Howe...

    Authors: Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley and Wei-Qun Ding

    Citation: Molecular Cancer 2015 14:133

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  17. Content type: Research

    Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (B...

    Authors: Nitesh Sharma, Vera Magistroni, Rocco Piazza, Stefania Citterio, Caterina Mezzatesta, Praveen Khandelwal, Alessandra Pirola and Carlo Gambacorti-Passerini

    Citation: Molecular Cancer 2015 14:132

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  18. Content type: Research

    Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore t...

    Authors: Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg and Khawla S. Al-Kuraya

    Citation: Molecular Cancer 2015 14:131

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  19. Content type: Research

    Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten ...

    Authors: Francesca De Amicis, Saveria Aquila, Catia Morelli, Carmela Guido, Marta Santoro, Ida Perrotta, Loredana Mauro, Francesca Giordano, Alessandra Nigro, Sebastiano Andò and Maria L. Panno

    Citation: Molecular Cancer 2015 14:130

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  20. Content type: Research

    Clinical trials designed to test the efficacy of retinoic acid (RA) as an adjuvant for the treatment of solid cancers have been disappointing, primarily due to RA resistance. Estrogen receptor (ER)-negative br...

    Authors: Rong-Zong Liu, Elizabeth Garcia, Darryl D. Glubrecht, Ho Yin Poon, John R. Mackey and Roseline Godbout

    Citation: Molecular Cancer 2015 14:129

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  21. Content type: Research

    Glioblastoma multiforme (GBM) is one of the most highly metastatic cancers. GBM has been associated with a high level of the mechanistic target of rapamycin complex 2 (mTORC2) activity. We aimed to observe rol...

    Authors: Naphat Chantaravisoot, Piriya Wongkongkathep, Joseph A. Loo, Paul S. Mischel and Fuyuhiko Tamanoi

    Citation: Molecular Cancer 2015 14:127

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  22. Content type: Research

    Defects in programmed cell death, or apoptosis, are a hallmark of cancer. The anti-apoptotic B-cell lymphoma 2 (BCL-2) family proteins, including BCL-2, BCL-XL, and MCL-1 have been characterized as key survival f...

    Authors: Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson and Lloyd T. Lam

    Citation: Molecular Cancer 2015 14:126

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  23. Content type: Erratum

    Authors: Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo and Antoni Ribas

    Citation: Molecular Cancer 2015 14:128

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    The original article was published in Molecular Cancer 2014 13:194

  24. Content type: Review

    RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malign...

    Authors: Tianzhen Wang, Guangyu Wang, Dapeng Hao, Xi Liu, Dong Wang, Ning Ning and Xiaobo Li

    Citation: Molecular Cancer 2015 14:125

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