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Molecular Cancer

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  1. Content type: Research

    Flavonoids are a diverse family of natural phenolic compounds commonly found in fruits and vegetables. Epidemiologic studies showed that flavonoids also reduce the risk of colon cancer. Tectochrysin is one of ...

    Authors: Mi Hee Park, Ji Eun Hong, Eun Sook Park, Hee Sung Yoon, Doo Won Seo, Byung Kook Hyun, Sang-Bae Han, Young Won Ham, Bang Yeon Hwang and Jin Tae Hong

    Citation: Molecular Cancer 2015 14:124

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  2. Content type: Research

    Although matrix metalloproteinase (MMP)-7 expression is correlated with increased metastatic potential in human colon cancer cells, the underlying molecular mechanism of invasive phenotype remains unknown. In ...

    Authors: Suhrid Banskota, Sushil C. Regmi and Jung-Ae Kim

    Citation: Molecular Cancer 2015 14:123

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  3. Content type: Research

    Docetaxel is the first chemotherapy agent approved for treatment of metastatic castration-resistant prostate cancer (mCRPC). The limited survival benefit associated with the quick emergence of resistance and s...

    Authors: Styliani Karanika, Theodoros Karantanos, Shinji Kurosaka, Jianxiang Wang, Takahiro Hirayama, Guang Yang, Sanghee Park, Alexei A. Golstov, Ryuta Tanimoto, Likun Li and Timothy C. Thompson

    Citation: Molecular Cancer 2015 14:122

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  4. Content type: Research

    Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral mem...

    Authors: Zhe Lu, Do Hyung Kim, Junming Fan, Qun Lu, Kathryn Verbanac, Lei Ding, Randall Renegar and Yan-Hua Chen

    Citation: Molecular Cancer 2015 14:120

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  5. Content type: Research

    Glioblastomas are invasive therapy resistant brain tumors with extremely poor prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance and tumor recurrence. Targeting GIC-as...

    Authors: Mrinal Joel, Awais A. Mughal, Zanina Grieg, Wayne Murrell, Sheryl Palmero, Birthe Mikkelsen, Hege B. Fjerdingstad, Cecilie J. Sandberg, Jinan Behnan, Joel C. Glover, Iver A. Langmoen and Biljana Stangeland

    Citation: Molecular Cancer 2015 14:121

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  6. Content type: Research

    Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell carc...

    Authors: De-Kuan Chang, Raymond J. Moniz, Zhongyao Xu, Jiusong Sun, Sabina Signoretti, Quan Zhu and Wayne A. Marasco

    Citation: Molecular Cancer 2015 14:119

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  7. Content type: Review

    Osteoprotegerin (OPG) is a secreted protein and member of the Tumor Necrosis Factor (TNF) Receptor superfamily. OPG has been well characterized as a regulator of bone metabolism which acts by blocking osteocla...

    Authors: Michael Weichhaus, Stephanie Tsang Mui Chung and Linda Connelly

    Citation: Molecular Cancer 2015 14:117

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  8. Content type: Research

    Present study provides clinical evidence of existence of a functional loop involving miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently reported by our group in an experimental setu...

    Authors: Gauri Shishodia, Shirish Shukla, Yogesh Srivastava, Shashank Masaldan, Sumita Mehta, Suresh Bhambhani, Shashi Sharma, Ravi Mehrotra, Bhudev Chandra Das and Alok Chandra Bharti

    Citation: Molecular Cancer 2015 14:116

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  9. Content type: Research

    The expression of the chemokine receptor CCR6 has been previously correlated with higher grades and stages of breast cancer and decreased relapse-free survival. Also, its cognate chemokine ligand CCL20 has bee...

    Authors: Sarah T. Boyle, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Citation: Molecular Cancer 2015 14:115

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  10. Content type: Research

    Much effort has been devoted to determining how metastatic cells and microenvironment reciprocally interact. However, the role of biological stimuli of microenvironment in controlling molecular events in bone ...

    Authors: Paola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio

    Citation: Molecular Cancer 2015 14:112

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  11. Content type: Research

    Therapeutic interventions in the insulin-like growth factor receptor (IGF-1R) pathway were expected to provide clinical benefits; however, IGF-1R tyrosine kinase inhibitors (TKIs) have shown limited antitumor ...

    Authors: Hye-Young Min, Hye Jeong Yun, Ji-Sun Lee, Hyo-Jong Lee, Jaebeom Cho, Hyun-Ji Jang, Shin-Hyung Park, Diane Liu, Seung-Hyun Oh, J. Jack Lee, Ignacio I. Wistuba and Ho-Young Lee

    Citation: Molecular Cancer 2015 14:113

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  12. Content type: Research

    Redox stress is a hallmark of the rewired metabolic phenotype of cancer. The underlying dysregulation of reactive oxygen species (ROS) is interconnected with abnormal mitochondrial biogenesis and function. In ...

    Authors: Christian Prinz, Elena Vasyutina, Gregor Lohmann, Alexandra Schrader, Steffen Romanski, Christoph Hirschhäuser, Petra Mayer, Corazon Frias, Carmen D. Herling, Michael Hallek, Hans-Günther Schmalz, Aram Prokop, Dimitrios Mougiakakos and Marco Herling

    Citation: Molecular Cancer 2015 14:114

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  13. Content type: Research

    Gene therapy has been an attractive paradigm for cancer treatment. However, cancer gene therapy has been challenged by the inherent limitation of vectors that are able to deliver therapeutic genes to tumors sp...

    Authors: Teerapong Yata, Eugene L. Q. Lee, Keittisak Suwan, Nelofer Syed, Paladd Asavarut and Amin Hajitou

    Citation: Molecular Cancer 2015 14:110

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  14. Content type: Research

    Integrins and enzymes of the eicosanoid pathway are both well-established contributors to cancer. However, this is the first report of the interdependence of the two signaling systems. In a screen for proteins...

    Authors: Keqin Tang, Yinlong Cai, Sangeeta Joshi, Elizabeth Tovar, Stephanie C. Tucker, Krishna Rao Maddipati, John D. Crissman, William T. Repaskey and Kenneth V. Honn

    Citation: Molecular Cancer 2015 14:111

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  15. Content type: Research

    Human pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies in the world and despite great efforts in research types of treatment remain limited. A frequently detected a...

    Authors: Bianca T. Hofmann, Laura Schlüter, Philip Lange, Baris Mercanoglu, Florian Ewald, Aljonna Fölster, Aeint-Steffen Picksak, Sönke Harder, Alexander T. El Gammal, Katharina Grupp, Cenap Güngör, Astrid Drenckhan, Hartmut Schlüter, Christoph Wagener, Jakob R. Izbicki, Manfred Jücker…

    Citation: Molecular Cancer 2015 14:109

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  16. Content type: Research

    Urothelial carcinoma (UC) is the fifth most common cancer in the developed world. Delineation of differentiation subtypes in UC highlighted the importance of aberrant differentiation. Understanding underlying ...

    Authors: Judith Heubach, Juliana Monsior, René Deenen, Günter Niegisch, Tibor Szarvas, Christian Niedworok, Wolfgang Arthur Schulz and Michèle Janine Hoffmann

    Citation: Molecular Cancer 2015 14:108

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  17. Content type: Review

    Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two decades, several studies have shown amplification and overexpression of Aurora kinase A (AURKA) in several GI malig...

    Authors: Ahmed Katsha, Abbes Belkhiri, Laura Goff and Wael El-Rifai

    Citation: Molecular Cancer 2015 14:106

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  18. Content type: Research

    Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable ...

    Authors: Carola H. Schrader, Markus Kolb, Karim Zaoui, Christa Flechtenmacher, Niels Grabe, Klaus-Josef Weber, Thomas Hielscher, Peter K. Plinkert and Jochen Hess

    Citation: Molecular Cancer 2015 14:107

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  19. Content type: Research

    Na/K-ATPase (NKA) is inhibited by perillyl alcohol (POH), a monoterpene used in the treatment of tumors, including brain tumors. The NKA α1 subunit is known to be superexpressed in glioblastoma cells (GBM). This ...

    Authors: Diogo Gomes Garcia, Hugo Caire de Castro-Faria-Neto, Camila Ignácio da Silva, Kauê Francisco Correa de Souza e Souza, Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Lidia Maria da Fonte de Amorim, Aline Soares Freire, Ricardo Erthal Santelli, Luan Pereira Diniz, Flávia Carvalho Alcantara Gomes, Mauro Velho de Castro Faria and Patrícia Burth

    Citation: Molecular Cancer 2015 14:105

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  20. Content type: Research

    Immunotherapy has been extensively pursed as a promising strategy for the treatment of cancer. Pattern-recognition receptors (PRRs) play important roles in triggering activation of innate and adaptive immunity...

    Authors: Jung Eun Koo, Seung Won Shin, Soong Ho Um and Joo Young Lee

    Citation: Molecular Cancer 2015 14:104

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  21. Content type: Research

    Melanoma is notorious for its propensity to metastasize, which makes treatment extremely difficult. Receptor tyrosine kinase c-Met is activated in human melanoma and is involved in melanoma progression and met...

    Authors: Hui-Hui Cao, Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Hui Guo, Ting Li, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Hua Yu and Zhi-Ling Yu

    Citation: Molecular Cancer 2015 14:103

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  22. Content type: Research

    Restin belongs to MAGE superfamily and is known as MAGE H1. Restin was firstly cloned from HL-60 cells treated with all-trans retinoic acid (ATRA). Previous studies showed a pro-apoptotic role of Restin in sev...

    Authors: Zhenduo Lu, Dechuang Jiao, Jianghua Qiao, Sen Yang, Min Yan, Shude Cui and Zhenzhen Liu

    Citation: Molecular Cancer 2015 14:102

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  23. Content type: Research

    Autophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, cer...

    Authors: Changchang Liu, Elise P DeRoo, Catherine Stecyk, Margaret Wolsey, Mateusz Szuchnicki and Engda G Hagos

    Citation: Molecular Cancer 2015 14:101

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  24. Content type: Research

    We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in ad...

    Authors: Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu and Wafik S El-Deiry

    Citation: Molecular Cancer 2015 14:99

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