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Page 15 of 43

  1. Content type: Research

    The human dicer1 gene has been predicted to produce several mRNA variants that encode truncated Dicer1 proteins of varying lengths. One of these Dicer1 variants, Dicer1e, was recently found to be differentially e...

    Authors: Liliana P Cantini, Lourdes M Andino, Christopher C Attaway, Betsy Butler, Anca Dumitriu, Aaron Blackshaw and Andrew Jakymiw

    Citation: Molecular Cancer 2014 13:190

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  2. Content type: Research

    The successful gene delivery into the brain is a major challenge due to the presence of the blood–brain barrier (BBB). In order to transport plasmid DNA across the BBB and target the brain glioma, the PEGylate...

    Authors: Pei-jian Yue, Lei He, Shu-wei Qiu, Yi Li, Yi-ji Liao, Xiang-pen Li, Dan Xie and Ying Peng

    Citation: Molecular Cancer 2014 13:191

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  3. Content type: Research

    Ovarian cancer (OCa) peritoneal metastasis is the leading cause of cancer–related deaths in women with limited therapeutic options available for treating it and poor prognosis, as the underlying mechanism is n...

    Authors: Kuo-Tai Hua, Ming-Yang Wang, Min-Wei Chen, Lin-Hung Wei, Chi-Kuan Chen, Ching-Huai Ko, Yung-Ming Jeng, Pi-Lin Sung, Yi-Hua Jan, Michael Hsiao, Min-Liang Kuo and Men-Luh Yen

    Citation: Molecular Cancer 2014 13:189

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  4. Content type: Research

    The molecular mechanisms underlying dysregulation of microRNAs have been documented in nasopharyngeal carcinoma (NPC). Our previous study demonstrated that plasma miR-124 was down-regulated in NPC using microa...

    Authors: Xiao Hong Peng, Hao Ran Huang, Juan Lu, Xiong Liu, Fei Peng Zhao, Bao Zhang, Shao Xiong Lin, Lu Wang, Huai Hong Chen, Xia Xu, Fan Wang and Xiang Ping Li

    Citation: Molecular Cancer 2014 13:186

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  5. Content type: Research

    As a distinctive type of head and neck cancers, nasopharyngeal carcinoma (NPC) is genesis from the clonal Epstein-Barr virus (EBV)-infected nasopharyngeal epithelial cells accumulated with multiple genetic les...

    Authors: Chartia Ching-Mei Cheung, Grace Tin-Yun Chung, Samantha Wei-Man Lun, Ka-Fai To, Kwong-Wai Choy, Kin-Mang Lau, Sharie Pui-Kei Siu, Xin-Yuan Guan, Roger Kai-Cheong Ngan, Timothy Tak-Chun Yip, Pierre Busson, Sai-Wah Tsao and Kwok-Wai Lo

    Citation: Molecular Cancer 2014 13:184

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  6. Content type: Research

    Tumor cells exhibit abnormal actin remodeling profiles, which involve the altered expressions of several important actin-binding proteins. Profilin1 (Pfn1), originally identified as an actin-associated protein...

    Authors: Wantong Yao, Shunrong Ji, Yi Qin, Jingxuan Yang, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Si Shi, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Min Li and Xianjun Yu

    Citation: Molecular Cancer 2014 13:187

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  7. Content type: Research

    Epithelioid sarcoma (EpS) is a high-grade malignant soft-tissue sarcoma characterized by local recurrences and distant metastases. Effective treatments for EpS have not been established and thus novel therapeu...

    Authors: Yoshinori Imura, Hirohiko Yasui, Hidetatsu Outani, Toru Wakamatsu, Kenichiro Hamada, Takaaki Nakai, Shutaro Yamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa and Norifumi Naka

    Citation: Molecular Cancer 2014 13:185

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  8. Content type: Research

    Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor s...

    Authors: Michael Rosemann, Iria Gonzalez-Vasconcellos, Tanja Domke, Virginija Kuosaite, Ralf Schneider, Markus Kremer, Jack Favor, Michaela Nathrath and Michael J Atkinson

    Citation: Molecular Cancer 2014 13:182

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  9. Content type: Research

    Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human canc...

    Authors: Qiao Zhang, Zhe Yang, Zhuqing Jia, Cuiling Liu, Chen Guo, Huafei Lu, Ping Chen, Kangtao Ma, Weiping Wang and Chunyan Zhou

    Citation: Molecular Cancer 2014 13:181

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  10. Content type: Research

    WRAP53, including α, β and γ isoforms, plays an important role not only in the stability of p53 mRNA, but also in the assembly and trafficking of the telomerase holoenzyme. It has been considered an oncogene a...

    Authors: Chong-kui Sun, Xiao-bo Luo, Ya-ping Gou, Ling Hu, Kun Wang, Chao Li, Zhen-ting Xiang, Ping Zhang, Xiang-li Kong, Chao-liang Zhang, Qin Yang, Jing Li, Li-ying Xiao, Yan Li and Qian-ming Chen

    Citation: Molecular Cancer 2014 13:180

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  11. Content type: Research

    A safe and effective adjuvant plays an important role in the development of a vaccine. However, adjuvants licensed for administration in humans remain limited. Here, for the first time, we developed a novel co...

    Authors: Meng Li, Huashan Shi, Yandong Mu, Zichao Luo, Hailong Zhang, Yang Wan, Dongmei Zhang, Lian Lu, Ke Men, Yaomei Tian, Xiaozhe Wu, Xiaoyan Liu, Ying Pan, Yingzi Fan, Chaoheng Yu, Bailing Zhou…

    Citation: Molecular Cancer 2014 13:179

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  12. Content type: Research

    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells have been implicated as important cells in antitumor responses. Our previous research has shown that high mobility group nucleosomal-binding domain 2...

    Authors: Lin Su, Ankang Hu, Yang Luo, Wenjie Zhou, Ping Zhang and Yun Feng

    Citation: Molecular Cancer 2014 13:178

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  13. Content type: Research

    Endothelial progenitor cells (EPCs) have been demonstrated to have stem-cell like as well as mature endothelial functions. However, controversy remains as to their origins, immunophenotypic markings, and contr...

    Authors: Jeffery S Russell and J Martin Brown

    Citation: Molecular Cancer 2014 13:177

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  14. Content type: Research

    Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic a...

    Authors: YingYing Qian, Shoujie Chai, Zuyu Liang, Yongfang Wang, You Zhou, Xia Xu, Chenchen Zhang, Min Zhang, Jingxing Si, Feiteng Huang, Zhangdan Huang, Wei Hong and Kai Wang

    Citation: Molecular Cancer 2014 13:176

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  15. Content type: Research

    microRNAs (miRNAs) play both oncogenic and oncostatic roles in leukemia. However, the molecular details underlying miRNA-mediated regulation of their target genes in pediatric B- and T-cell acute lymphoblastic...

    Authors: Deepti Malik, Deepak Kaul, Nalini Chauhan and Ram Kumar Marwaha

    Citation: Molecular Cancer 2014 13:175

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  16. Content type: Research

    Triple negative breast cancer (TNBC) is characterized by lack of expression of both estrogen and progesterone receptor as well as lack of overexpression or amplification of HER2. Despite an increased probabili...

    Authors: Christof Bernemann, Carolin Hülsewig, Christian Ruckert, Sarah Schäfer, Lena Blümel, Georg Hempel, Martin Götte, Burkhard Greve, Peter J Barth, Ludwig Kiesel and Cornelia Liedtke

    Citation: Molecular Cancer 2014 13:174

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  17. Content type: Research

    Inhibitor of DNA binding/Differentiation 1 (ID1) is a helix loop helix transcription factor that lacks the basic DNA binding domain. Over-expression of ID1 has been correlated with a variety of human cancers; ...

    Authors: Sajitha Nair, Namrata Bora-Singhal, Deepak Perumal and Srikumar Chellappan

    Citation: Molecular Cancer 2014 13:173

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  18. Content type: Research

    Long non-coding RNAs (lncRNAs) are recognized as pivotal players during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA (miRNA) clusters miR-99a ~ 125b-2 and miR-100 ~ 125b-1 promote p...

    Authors: Stephan Emmrich, Alexandra Streltsov, Franziska Schmidt, Veera Raghavan Thangapandi, Dirk Reinhardt and Jan-Henning Klusmann

    Citation: Molecular Cancer 2014 13:171

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  19. Content type: Research

    Head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide. Emerging evidence indicates that alteration of epigenetics might be a key event in HNSCC progression. Abnormal expression of histone ...

    Authors: Kai-Chun Li, Kuo-Tai Hua, Yi-Shen Lin, Chia-Yi Su, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan

    Citation: Molecular Cancer 2014 13:172

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  20. Content type: Research

    Recent findings indicate that exosomes released from cancer cells contain microRNAs (miRNAs) that may be delivered to cells of tumor microenvironment.

    Authors: Simona Taverna, Valeria Amodeo, Laura Saieva, Antonio Russo, Marco Giallombardo, Giacomo De Leo and Riccardo Alessandro

    Citation: Molecular Cancer 2014 13:169

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  21. Content type: Research

    Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of ...

    Authors: Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin and Khawla S Al-Kuraya

    Citation: Molecular Cancer 2014 13:168

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  22. Content type: Research

    The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this regar...

    Authors: Jillian L Pope, Rizwan Ahmad, Ajaz A Bhat, Mary K Washington, Amar B Singh and Punita Dhawan

    Citation: Molecular Cancer 2014 13:167

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  23. Content type: Research

    Growing evidence indicates that miR-200c is involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological role remains largely elusive.

    Authors: Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong, Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He and Ming Yao

    Citation: Molecular Cancer 2014 13:166

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  24. Content type: Research

    Docetaxel resistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote autophagy protection in response to antitumor t...

    Authors: Banzhou Pan, Dongqin Chen, Jiayuan Huang, Rui Wang, Bing Feng, Haizhu Song and Longbang Chen

    Citation: Molecular Cancer 2014 13:165

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  25. Content type: Research

    The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The ...

    Authors: Michal Caspi, Gili Perry, Nir Skalka, Shilhav Meisel, Anastasia Firsow, Maayan Amit and Rina Rosin-Arbesfeld

    Citation: Molecular Cancer 2014 13:164

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  26. Content type: Research

    Translational exploration of bacterial toxins has come to the forefront of research given their potential as a chemotherapeutic tool. Studies in select tissues have demonstrated that Clostridium perfringens iota ...

    Authors: Katerina D Fagan-Solis, Denise K Reaves, M Cristina Rangel, Michel R Popoff, Bradley G Stiles and Jodie M Fleming

    Citation: Molecular Cancer 2014 13:163

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  27. Content type: Research

    The thyroid hormone, 3, 3′, 5-triiodo-L-thyronine (T3), has been shown to modulate cellular processes via interactions with thyroid hormone receptors (TRs), but the secretory proteins that are regulated to exert ...

    Authors: Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Chie-Pein Chen, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai and Kwang-Huei Lin

    Citation: Molecular Cancer 2014 13:162

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  28. Content type: Research

    Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in sev...

    Authors: Gennaro Di Maro, Paolo Salerno, Kristian Unger, Francesca Maria Orlandella, Mario Monaco, Gennaro Chiappetta, Gerry Thomas, Malgorzata Oczko-Wojciechowska, Mariorosario Masullo, Barbara Jarzab, Massimo Santoro and Giuliana Salvatore

    Citation: Molecular Cancer 2014 13:160

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  29. Content type: Research

    Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma associated with poor prognosis. Implementation of high-dose cytarabine (araC) into induction therapy became standard-of-care for ...

    Authors: Magdalena Klanova, Lucie Lorkova, Ondrej Vit, Bokang Maswabi, Jan Molinsky, Jana Pospisilova, Petra Vockova, Cory Mavis, Lucie Lateckova, Vojtech Kulvait, Dana Vejmelkova, Radek Jaksa, Francisco Hernandez, Marek Trneny, Martin Vokurka, Jiri Petrak…

    Citation: Molecular Cancer 2014 13:159

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  30. Content type: Research

    Metronomic cyclophosphamide given on an intermittent, 6-day repeating schedule, but not on an exposure dose-equivalent daily schedule, activates an anti-tumor innate immune response that leads to major regress...

    Authors: Joshua C Doloff, Chong-Sheng Chen and David J Waxman

    Citation: Molecular Cancer 2014 13:158

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  31. Content type: Research

    HER2 targeted therapies including trastuzumab and more recently lapatinib have significantly improved the prognosis for HER2 positive breast cancer patients. However, resistance to these agents is a significan...

    Authors: Martina S J McDermott, Brigid C Browne, Neil T Conlon, Neil A O’Brien, Dennis J Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown and Norma O’Donovan

    Citation: Molecular Cancer 2014 13:157

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  32. Content type: Research

    Protein coding genes account for only about 2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs including long non-coding RNAs. A growing volume of literature has proposed that...

    Authors: Ming-zhe Ma, Chun-xiao Li, Yan Zhang, Ming-zhe Weng, Ming-di Zhang, Yi-yu Qin, Wei Gong and Zhi-wei Quan

    Citation: Molecular Cancer 2014 13:156

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  33. Content type: Research

    With increased long-term survivors of childhood cancer patients, therapy-associated infertility has become one of the most common late side-effects and significantly affects their life-quality. Therefore, eval...

    Authors: Mi Hou, Emma Eriksson, Konstantin Svechnikov, Kirsi Jahnukainen, Olle Söder, Andreas Meinhardt and Lars Sävendahl

    Citation: Molecular Cancer 2014 13:155

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  34. Content type: Research

    The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent. In melanoma, the existence of a BRAF mutation is a main predictor for succ...

    Authors: Imanol Arozarena, Ibai Goicoechea, Oihane Erice, Jennnifer Ferguson, Geoffrey P Margison and Claudia Wellbrock

    Citation: Molecular Cancer 2014 13:154

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  35. Content type: Research

    The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potent...

    Authors: Changhua Zhuo, Zhiyuan Li, Ye Xu, Yuwei Wang, Qingguo Li, Junjie Peng, Hongtu Zheng, Peng Wu, Bin Li and Sanjun Cai

    Citation: Molecular Cancer 2014 13:153

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  36. Content type: Research

    Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development.

    Authors: Eva Juengel, Snigdha Nowaz, Jasmina Makarevi, Iyad Natsheh, Isabella Werner, Karen Nelson, Michael Reiter, Igor Tsaur, Jens Mani, Sebastian Harder, Georg Bartsch, Axel Haferkamp and Roman A Blaheta

    Citation: Molecular Cancer 2014 13:152

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  37. Content type: Research

    Epidemiological data show that the incidence of carcinomas in humans is highly dependent on age. However, the initial steps of the age-related molecular oncogenic processes by which the switch towards the neop...

    Authors: Nathalie Martin, Clara Salazar-Cardozo, Chantal Vercamer, Louise Ott, Guillemette Marot, Predrag Slijepcevic, Corinne Abbadie and Olivier Pluquet

    Citation: Molecular Cancer 2014 13:151

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  38. Content type: Research

    Heat shock protein 90 (Hsp90) is a promising therapeutic target and inhibition of Hsp90 will presumably result in suppression of multiple signaling pathways. FW-04-806, a bis-oxazolyl macrolide compound extrac...

    Authors: Wei Huang, Min Ye, Lian-ru Zhang, Qun-dan Wu, Min Zhang, Jian-hua Xu and Wei Zheng

    Citation: Molecular Cancer 2014 13:150

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  39. Content type: Research

    Peroxisome proliferator-activated receptors gamma (PPARγ) ligands have been shown to inhibit the growth of non-small cell lung cancer (NSCLC) cells. However, the mechanisms underlying this effect remain incomp...

    Authors: SWei Sunny Hann, Qing Tang, Fang Zheng, Shunyu Zhao, Jianping Chen and ZhiYu Wang

    Citation: Molecular Cancer 2014 13:149

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  40. Content type: Research

    Resistance to cell death in the presence of stressful stimuli is one of the hallmarks of cancer cells acquired during multistep tumorigenesis, and knowledge of the molecular mechanism of stress adaptation can ...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim and Byoung Heon Kang

    Citation: Molecular Cancer 2014 13:148

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  41. Content type: Research

    Chk1 forms a core component of the DNA damage response and small molecule inhibitors are currently being investigated in the clinic as cytotoxic chemotherapy potentiators. Recent evidence suggests that Chk1 in...

    Authors: Christopher Bryant, Kirsten Scriven and Andrew J Massey

    Citation: Molecular Cancer 2014 13:147

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  42. Content type: Research

    The Abelson tyrosine kinase (c-Abl) inhibitor STI571 (Glivec®) has been shown to effectively inhibit colorectal cancer cell migration and invasion. The c-Abl substrate abelson interactor 1 (Abi1) is a key regu...

    Authors: Konrad Steinestel, Silke Brüderlein, Jochen K Lennerz, Julie Steinestel, Klaus Kraft, Christian Pröpper, Viktor Meineke and Peter Möller

    Citation: Molecular Cancer 2014 13:145

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  43. Content type: Research

    High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NFκB and Hedgehog (Hh) signaling pathways are in...

    Authors: Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker and Rainer Schneider

    Citation: Molecular Cancer 2014 13:146

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  44. Content type: Research

    HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence for reported HER-2 overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. More...

    Authors: Daniele Cretella, Francesca Saccani, Federico Quaini, Caterina Frati, Costanza Lagrasta, Mara Bonelli, Cristina Caffarra, Andrea Cavazzoni, Claudia Fumarola, Maricla Galetti, Silvia La Monica, Luca Ampollini, Marcello Tiseo, Andrea Ardizzoni, Pier Giorgio Petronini and Roberta R Alfieri

    Citation: Molecular Cancer 2014 13:143

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