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  1. Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result of promoter hypermethylation. Contradictory re...

    Authors: Inga Peters, Kristina Rehmet, Nadine Wilke, Markus A Kuczyk, Jörg Hennenlotter, Tyark Eilers, Stefan Machtens, Udo Jonas and Jürgen Serth

    Citation: Molecular Cancer 2007 6:49

    Content type: Research

    Published on:

  2. Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-canc...

    Authors: Hiroyuki Kashiwagi, Jonathan E McDunn, Peter O Simon Jr, Peter S Goedegebuure, Jinbin Xu, Lynne Jones, Katherine Chang, Fabian Johnston, Kathryn Trinkaus, Richard S Hotchkiss, Robert H Mach and William G Hawkins

    Citation: Molecular Cancer 2007 6:48

    Content type: Research

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  3. Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests he...

    Authors: Emmanuel Rousseau, Thomas Palm, Francesco Scaravilli, Marie-Magdeleine Ruchoux, Dominique Figarella-Branger, Isabelle Salmon, David Ellison, Catherine Lacroix, Françoise Chapon, Jacqueline Mikol, Miikka Vikkula and Catherine Godfraind

    Citation: Molecular Cancer 2007 6:47

    Content type: Research

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  4. Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to...

    Authors: Tapas K Sengupta, Gilles M Leclerc, Ting Ting Hsieh-Kinser, Guy J Leclerc, Inderjit Singh and Julio C Barredo

    Citation: Molecular Cancer 2007 6:46

    Content type: Research

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  5. The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) and their in vitro ...

    Authors: Qinghua Wu, Ragnhild A Lothe, Terje Ahlquist, Ilvars Silins, Claes G Tropé, Francesca Micci, Jahn M Nesland, Zhenhe Suo and Guro E Lind

    Citation: Molecular Cancer 2007 6:45

    Content type: Research

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  6. Angiogenesis is a fundamental process that allows tumor growth by providing nutrients and oxygen to the tumor cells. Beyond the oxygen diffusion limit from a capillary blood vessel, tumor cells become apoptoti...

    Authors: Thaysa Paschoalin, Adriana K Carmona, Elaine G Rodrigues, Vitor Oliveira, Hugo P Monteiro, Maria A Juliano, Luiz Juliano and Luiz R Travassos

    Citation: Molecular Cancer 2007 6:44

    Content type: Research

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  7. Sovereign power is retained and shared by the citizens of a country. Using electoral tools, governing structures are formed to ensure protection of national interests. As with any institution, proper control o...

    Authors: Shawn Mathur and Christian Schmidt

    Citation: Molecular Cancer 2007 6:43

    Content type: Editorial

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  8. The role of TNF-α in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-α, others provide evidence that endogenous TNF-α promotes growth and de...

    Authors: Pabbisetty Sudheer Kumar, Anjali Shiras, Gowry Das, Jayashree C Jagtap, Vandna Prasad and Padma Shastry

    Citation: Molecular Cancer 2007 6:42

    Content type: Research

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  9. The cRGD peptide is a promising probe for early non-invasive detection of tumors. This study aimed to demonstrate how RAFT-c(-RGDfK-)4, a molecule allowing a tetrameric presentation of cRGD, improved cRGD-targeti...

    Authors: Zhao-Hui Jin, Véronique Josserand, Stéphanie Foillard, Didier Boturyn, Pascal Dumy, Marie-Christine Favrot and Jean-Luc Coll

    Citation: Molecular Cancer 2007 6:41

    Content type: Research

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  10. LIM kinase 1 (LIMK1), a LIM domain containing serine/threonine kinase, modulates actin dynamics through inactivation of the actin depolymerizing protein cofilin. Recent studies have indicated an important role...

    Authors: Monica Davila, Darshana Jhala, Debashis Ghosh, William E Grizzle and Ratna Chakrabarti

    Citation: Molecular Cancer 2007 6:40

    Content type: Research

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  11. The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in dise...

    Authors: Unnati Jariwala, Jennifer Prescott, Li Jia, Artem Barski, Steve Pregizer, Jon P Cogan, Armin Arasheben, Wayne D Tilley, Howard I Scher, William L Gerald, Grant Buchanan, Gerhard A Coetzee and Baruch Frenkel

    Citation: Molecular Cancer 2007 6:39

    Content type: Research

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  12. The androgen receptor is a ligand-induced transcriptional factor, which plays an important role in normal development of the prostate as well as in the progression of prostate cancer to a hormone refractory st...

    Authors: Katia Margiotti, Latif A Wafa, Helen Cheng, Giuseppe Novelli, Colleen C Nelson and Paul S Rennie

    Citation: Molecular Cancer 2007 6:38

    Content type: Research

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  13. The normal human prostate glandular epithelium has the unique function of accumulating high levels of zinc. In prostate cancer this capability is lost as an early event in the development of the malignant cell...

    Authors: Mohamed M Desouki, Joseph Geradts, Beatrice Milon, Renty B Franklin and Leslie C Costello

    Citation: Molecular Cancer 2007 6:37

    Content type: Research

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  14. A novel alkylating agent, temozolomide, has proven efficacious in the treatment of malignant gliomas. However, expression of O 6 -methylguanine-DNA methyltransferase (MGMT) r...

    Authors: Ken Sasai, Tsuyoshi Akagi, Eiko Aoyanagi, Kouichi Tabu, Sadao Kaneko and Shinya Tanaka

    Citation: Molecular Cancer 2007 6:36

    Content type: Research

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  15. Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typ...

    Authors: Delong Liu, Josif Shimonov, Suneeta Primanneni, Yongrong Lai, Tauseef Ahmed and Karen Seiter

    Citation: Molecular Cancer 2007 6:35

    Content type: Short communication

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  16. The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis. Many of these activities are initiated or enhanced by uPAR binding ...

    Authors: Mohammad Hasanuzzaman, Robert Kutner, Siamak Agha-Mohammadi, Jakob Reiser and Inder Sehgal

    Citation: Molecular Cancer 2007 6:34

    Content type: Research

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  17. Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest indep...

    Authors: Line Wergeland, Gry Sjøholt, Ingvild Haaland, Randi Hovland, Øystein Bruserud and Bjørn Tore Gjertsen

    Citation: Molecular Cancer 2007 6:33

    Content type: Research

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  18. Correlations of disease phenotypes with glycosylation changes have been analysed intensively in the tumor biology field. Glycoforms potentially associated with carcinogenesis, tumor progression and cancer meta...

    Authors: Takeaki Kudo, Hiroaki Nakagawa, Masato Takahashi, Jun Hamaguchi, Naoya Kamiyama, Hideki Yokoo, Kazuaki Nakanishi, Takahito Nakagawa, Toshiya Kamiyama, Kisaburo Deguchi, Shin-Ichiro Nishimura and Satoru Todo

    Citation: Molecular Cancer 2007 6:32

    Content type: Research

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  19. Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by compar...

    Authors: Tien-sheng Huang, Line M Myklebust, Endre Kjarland, Bjørn Tore Gjertsen, Frederic Pendino, Øystein Bruserud, Stein Ove Døskeland and Johan R Lillehaug

    Citation: Molecular Cancer 2007 6:31

    Content type: Research

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  20. Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target for cancer therapy. EGFR is frequently amplified in glioblastomas and 30 to 40% of glioblastomas also express the deleti...

    Authors: Dimitri G Trembath, Anita Lal, David J Kroll, Nicholas H Oberlies and Gregory J Riggins

    Citation: Molecular Cancer 2007 6:30

    Content type: Research

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  21. Inflammation is increasingly recognized as an important component of tumorigenesis, although the mechanisms involved are not fully characterized. The invasive capacity of cancers is reflected in the classic me...

    Authors: José-Ignacio Arias, María-Angeles Aller and Jaime Arias

    Citation: Molecular Cancer 2007 6:29

    Content type: Hypothesis

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  22. The latency-associated nuclear antigen (LANA-1) of Human Herpes Virus 8 (HHV-8), alternatively called Kaposi Sarcoma Herpes Virus (KSHV) is constitutively expressed in all HHV-8 infected cells. LANA-1 accumula...

    Authors: György Stuber, Karin Mattsson, Emilie Flaberg, Emrah Kati, Laszlo Markasz, Julie A Sheldon, George Klein, Thomas F Schulz and Laszlo Szekely

    Citation: Molecular Cancer 2007 6:28

    Content type: Research

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  23. Bright/ARID3A is a nuclear matrix-associated transcription factor that stimulates immunoglobulin heavy chain (IgH) expression and Cyclin E1/E2F-dependent cell cycle progression. Bright positively activates IgH...

    Authors: Danjuan Lin, Gregory C Ippolito, Rui-Ting Zong, James Bryant, Janet Koslovsky and Philip Tucker

    Citation: Molecular Cancer 2007 6:23

    Content type: Research

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  24. The blood-brain tumor barrier (BTB) impedes the delivery of therapeutic agents to brain tumors. While adequate delivery of drugs occurs in systemic tumors, the BTB limits delivery of anti-tumor agents into bra...

    Authors: Jinwei Hu, Xiangpeng Yuan, MinHee K Ko, Dali Yin, Manuel R Sacapano, Xiao Wang, Bindu M Konda, Andres Espinoza, Ksenia Prosolovich, John M Ong, Dwain Irvin and Keith L Black

    Citation: Molecular Cancer 2007 6:22

    Content type: Research

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  25. microRNAs (miRNAs) are a group of non-coding single stranded RNAs measuring approximately 22 nucleotides in length that have been found to control cell growth, differentiation and apoptosis. They negatively re...

    Authors: Susanne Cahill, Paul Smyth, Karen Denning, Richard Flavin, Jinghuan Li, Astrid Potratz, Simone M Guenther, Richard Henfrey, John J O'Leary and Orla Sheils

    Citation: Molecular Cancer 2007 6:21

    Content type: Research

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  26. Robust Hedgehog (Hh) signaling has been implicated as a common feature of human prostate cancer and an important stimulus of tumor growth. The role of Hh signaling has been studied in several xenograft tumor m...

    Authors: Jerry Gipp, Guangyu Gu, Curtis Crylen, Susan Kasper and Wade Bushman

    Citation: Molecular Cancer 2007 6:19

    Content type: Research

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  27. Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals.

    Authors: Linda Ulazzi, Silvia Sabbioni, Elena Miotto, Angelo Veronese, Angela Angusti, Roberta Gafà, Stefano Manfredini, Fabio Farinati, Takako Sasaki, Giovanni Lanza and Massimo Negrini

    Citation: Molecular Cancer 2007 6:17

    Content type: Research

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  28. The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and di...

    Authors: Pei-Yin Lin, Susan P Fosmire, See-Hyoung Park, Jin-Young Park, Shairaz Baksh, Jaime F Modiano and Robert H Weiss

    Citation: Molecular Cancer 2007 6:16

    Content type: Research

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  29. The Cox proportional hazards model is the most widely used model for survival analysis because of its simplicity. The fundamental assumption in this model is the proportionality of the hazard function. When th...

    Authors: Farid E Ahmed, Paul W Vos and Don Holbert

    Citation: Molecular Cancer 2007 6:15

    Content type: Hypothesis

    Published on:

  30. Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated wit...

    Authors: Wolfgang A Schulz, Adrian Alexa, Volker Jung, Christiane Hader, Michèle J Hoffmann, Masanori Yamanaka, Sandy Fritzsche, Agnes Wlazlinski, Mirko Müller, Thomas Lengauer, Rainer Engers, Andrea R Florl, Bernd Wullich and Jörg Rahnenführer

    Citation: Molecular Cancer 2007 6:14

    Content type: Research

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  31. The consecutive acquisition of genetic alterations characterizes neoplastic processes. As a consequence of these alterations, molecular interactions are reprogrammed in the context of highly connected and regu...

    Authors: Pilar Hernández, Xavier Solé, Joan Valls, Víctor Moreno, Gabriel Capellá, Ander Urruticoechea and Miguel Angel Pujana

    Citation: Molecular Cancer 2007 6:13

    Content type: Research

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  32. Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events in the develop...

    Authors: Christina E Hoei-Hansen, Sigrid M Kraggerud, Vera M Abeler, Janne Kærn, Ewa Rajpert-De Meyts and Ragnhild A Lothe

    Citation: Molecular Cancer 2007 6:12

    Content type: Research

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  33. Aberrant methylation of gene promoter regions has been linked to changes in gene expression in cancer development and progression. Genes associated with CpG islands (CGIs) are especially prone to methylation, ...

    Authors: Laura Menendez, DeEtte Walker, Lilya V Matyunina, Erin B Dickerson, Nathan J Bowen, Nalini Polavarapu, Benedict B Benigno and John F McDonald

    Citation: Molecular Cancer 2007 6:10

    Content type: Research

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  34. Sapphyrin analogues and related porphyrin-like species have attracted attention as anticancer agents due to their selective localization in various cancers, including hematologic malignancies, relative to surr...

    Authors: Zhong Wang, Philip S Lecane, Patricia Thiemann, Qing Fan, Cecilia Cortez, Xuan Ma, Danielle Tonev, Dale Miles, Louie Naumovski, Richard A Miller, Darren Magda, Dong-Gyu Cho, Jonathan L Sessler, Brian L Pike, Samantha M Yeligar, Mazen W Karaman…

    Citation: Molecular Cancer 2007 6:9

    Content type: Research

    Published on:

  35. Malignant melanoma is one of the most aggressive skin cancer and chemotherapeutic agents currently in use are still unsatisfactory. Prevention and early diagnosis are the only effective tools against this tumo...

    Authors: Marina Pisano, Gabriella Pagnan, Monica Loi, Maria Elena Mura, Maria Giovanna Tilocca, Giuseppe Palmieri, Davide Fabbri, Maria Antonietta Dettori, Giovanna Delogu, Mirco Ponzoni and Carla Rozzo

    Citation: Molecular Cancer 2007 6:8

    Content type: Research

    Published on:

  36. Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome a...

    Authors: Yizheng Li, Jing Pan, Jian-Liang Li, Jee Hyung Lee, Chris Tunkey, Katie Saraf, James C Garbe, Maryann Z Whitley, Scott A Jelinsky, Martha R Stampfer and Steven A Haney

    Citation: Molecular Cancer 2007 6:7

    Content type: Research

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  37. Osteopontin (OPN), a secreted phosphoglycoprotein, has been strongly associated with tumor progression and aggressive cancers. MDA-MB-435 cells secrete very high levels of OPN. However metastasis-suppressed MD...

    Authors: Rajeev S Samant, David W Clark, Rebecca A Fillmore, Muzaffer Cicek, Brandon J Metge, Kondethimmana H Chandramouli, Ann F Chambers, Graham Casey, Danny R Welch and Lalita A Shevde

    Citation: Molecular Cancer 2007 6:6

    Content type: Research

    Published on:

  38. HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells. Although the roles of signaling cascades a...

    Authors: Carla Hebert, Kathleen Norris, Mark A Scheper, Nikolaos Nikitakis and John J Sauk

    Citation: Molecular Cancer 2007 6:5

    Content type: Research

    Published on:

  39. Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas a...

    Authors: Carolina Cristina, Graciela S Díaz-Torga, Rodolfo G Goya, Sham S Kakar, María I Perez-Millán, Vanessa Q Passos, Daniel Giannella-Neto, Marcello D Bronstein and Damasia Becu-Villalobos

    Citation: Molecular Cancer 2007 6:4

    Content type: Research

    Published on:

  40. Epigenetic silencing of regulatory genes by aberrant methylation contributes to tumorigenesis. DNA methyltransferase inhibitors (DNMTI) represent promising new drugs for anti-cancer therapies. The DNMTI 5-Azac...

    Authors: Sieta P Rao, Markus P Rechsteiner, Christoph Berger, Jürg A Sigrist, David Nadal and Michele Bernasconi

    Citation: Molecular Cancer 2007 6:3

    Content type: Short communication

    Published on:

  41. Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the overall gene ex...

    Authors: Kristine Kleivi, Guro E Lind, Chieu B Diep, Gunn I Meling, Lin T Brandal, Jahn M Nesland, Ola Myklebost, Torleiv O Rognum, Karl-Erik Giercksky, Rolf I Skotheim and Ragnhild A Lothe

    Citation: Molecular Cancer 2007 6:2

    Content type: Research

    Published on:

  42. Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been st...

    Authors: Michael B Ujiki, Xian-Zhong Ding, M Reza Salabat, David J Bentrem, Laleh Golkar, Ben Milam, Mark S Talamonti, Richard H Bell Jr, Takeshi Iwamura and Thomas E Adrian

    Citation: Molecular Cancer 2006 5:76

    Content type: Research

    Published on:

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