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  1. Younger women with breast carcinoma (BC) exhibits more aggressive pathologic features compared to older women; young age could be an independent predictor of adverse prognosis. To find any existing differences...

    Authors: Satyabrata Sinha, Ratnesh K Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury and Chinmay Kumar Panda

    Citation: Molecular Cancer 2008 7:84

    Content type: Research

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  2. Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of ...

    Authors: Alfonso Dueñas-González, Patricia García-López, Luis Alonso Herrera, Jose Luis Medina-Franco, Aurora González-Fierro and Myrna Candelaria

    Citation: Molecular Cancer 2008 7:82

    Content type: Review

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  3. Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic leukemia (T-ALL)...

    Authors: Maria Corsignano Guastadisegni, Angelo Lonoce, Luciana Impera, Francesco Albano, Pietro D'Addabbo, Sebastiano Caruso, Isabella Vasta, Ioannis Panagopoulos, Anna Leszl, Giuseppe Basso, Mariano Rocchi and Clelia Tiziana Storlazzi

    Citation: Molecular Cancer 2008 7:80

    Content type: Short communication

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  4. The functional status of a cell is expressed in its metabolic activity. We have applied stable isotope tracing methods to determine the differences in metabolic pathways in proliferating Rhabdomysarcoma cells ...

    Authors: Teresa WM Fan, Magda Kucia, Kacper Jankowski, Richard M Higashi, Janina Ratajczak, Marius Z Ratajczak and Andrew N Lane

    Citation: Molecular Cancer 2008 7:79

    Content type: Research

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  5. Constitutive activation of signal transducer and activator of transcription 3 (Stat3) signaling pathway plays an important role in several human cancers. Activation of Stat3 is dependent on the phosphorylation...

    Authors: Chun-Liang Chen, Ling Cen, Jennifer Kohout, Brian Hutzen, Christina Chan, Fu-Chuan Hsieh, Abbey Loy, Victor Huang, Gong Cheng and Jiayuh Lin

    Citation: Molecular Cancer 2008 7:78

    Content type: Research

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  6. The c-Myb protein is a transcriptional regulator initially identified by homology to the v-Myb oncoprotein, and has since been implicated in human cancer. The most highly conserved portion of the c-Myb protein...

    Authors: Emily Ray Ko, Dennis Ko, Carolyn Chen and Joseph S Lipsick

    Citation: Molecular Cancer 2008 7:77

    Content type: Research

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  7. The use of human embryonic stem cells (hESCs) in research is increasing and hESCs hold the promise for many biological, clinical and toxicological studies. Human ESCs are expected to be chromosomally stable si...

    Authors: Puri Catalina, Rosa Montes, Gertru Ligero, Laura Sanchez, Teresa de la Cueva, Clara Bueno, Paola E Leone and Pablo Menendez

    Citation: Molecular Cancer 2008 7:76

    Content type: Short communication

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  8. Barrett's esophagus (BE) is the metaplastic replacement of squamous with columnar epithelium in the esophagus, as a result of reflux. It is the major risk factor for the development of esophageal adenocarcinom...

    Authors: Eric Smith, Neville J De Young, Sandra J Pavey, Nicholas K Hayward, Derek J Nancarrow, David C Whiteman, B Mark Smithers, Andrew R Ruszkiewicz, Andrew D Clouston, David C Gotley, Peter G Devitt, Glyn G Jamieson and Paul A Drew

    Citation: Molecular Cancer 2008 7:75

    Content type: Research

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  9. MicroRNA (miRNA) dysregulation frequently occurs in cancer. Analysis of whole blood miRNA in tumor models has not been widely reported, but could potentially lead to novel assays for early detection and monito...

    Authors: Alice C Fan, Marianna M Goldrick, Jennifer Ho, Yu Liang, Pavan Bachireddy and Dean W Felsher

    Citation: Molecular Cancer 2008 7:74

    Content type: Short communication

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  10. β-catenin is a key mediator of the canonical Wnt pathway as it associates with members of the T-cell factor (TCF) family at Wnt-responsive promoters to drive the transcription of Wnt target genes. Recently, we...

    Authors: Pinella Buongiorno, Vaijayanti V Pethe, George S Charames, Susmita Esufali and Bharati Bapat

    Citation: Molecular Cancer 2008 7:73

    Content type: Research

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  11. Apart from genetic alterations, development and progression of colorectal cancer has been linked to influences from nutritional intake, hyperalimentation, and cellular metabolic changes that may be the basis f...

    Authors: Carsten Denkert, Jan Budczies, Wilko Weichert, Gert Wohlgemuth, Martin Scholz, Tobias Kind, Silvia Niesporek, Aurelia Noske, Anna Buckendahl, Manfred Dietel and Oliver Fiehn

    Citation: Molecular Cancer 2008 7:72

    Content type: Research

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  12. To investigate the expression of EPLIN-α, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-α on breast cancer cells.

    Authors: Wen G Jiang, Tracey A Martin, Jonathan M Lewis-Russell, Anthony Douglas-Jones, Lin Ye and Robert E Mansel

    Citation: Molecular Cancer 2008 7:71

    Content type: Research

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  13. Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes. HDAC inhibitors (HDACi) induce g...

    Authors: Marielle Dejligbjerg, Morten Grauslund, Thomas Litman, Laura Collins, Xiaozhong Qian, Michael Jeffers, Henri Lichenstein, Peter Buhl Jensen and Maxwell Sehested

    Citation: Molecular Cancer 2008 7:70

    Content type: Research

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  14. We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene...

    Authors: Hassan Brim, Pooneh Mokarram, Fakhraddin Naghibalhossaini, Mehdi Saberi-Firoozi, Mansour Al-Mandhari, Kamla Al-Mawaly, Rayhaneh Al-Mjeni, Abeer Al-Sayegh, Sandy Raeburn, Edward Lee, Francis Giardiello, Duane T Smoot, Alexander Vilkin, C Richard Boland, Ajay Goel, Mitra Hafezi…

    Citation: Molecular Cancer 2008 7:68

    Content type: Research

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  15. Childhood pre-B acute lymphoblastic leukemia (ALL) is a bone marrow (BM) derived disease, which often disseminates out of the BM cavity, where malignant cells to a variable degree can be found circulating in t...

    Authors: Frida Hansson, Jacek Toporski, Robert Månsson, Bertil Johansson, Ulrika Norén-Nyström, Sten Eirik W Jacobsen, Thomas Wiebe, Marcus Larsson, Mikael Sigvardsson and Anders Castor

    Citation: Molecular Cancer 2008 7:67

    Content type: Research

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  16. The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours...

    Authors: Elena Morandi, Cinzia Severini, Daniele Quercioli, Giovanni D'Ario, Stefania Perdichizzi, Miriam Capri, Giovanna Farruggia, Maria Grazia Mascolo, Wolfango Horn, Monica Vaccari, Roberto Serra, Annamaria Colacci and Paola Silingardi

    Citation: Molecular Cancer 2008 7:66

    Content type: Research

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  17. Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved...

    Authors: Rainer Hamacher, Roland M Schmid, Dieter Saur and Günter Schneider

    Citation: Molecular Cancer 2008 7:64

    Content type: Review

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  18. By nature, scientists contribute to our understanding of nature and ourselves. As communities undergo significant changes, new challenges are presented. Here, we offer alternative views on recent changes in so...

    Authors: Laura M Christian, Hassan R Naqvi, Christian Schmidt, David Covarrubias and Shawn Mathur

    Citation: Molecular Cancer 2008 7:63

    Content type: Editorial

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  19. Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this disease every year. The five-year survival rate is 15% – significan...

    Authors: Paul P Anglim, Janice S Galler, Michael N Koss, Jeffrey A Hagen, Sally Turla, Mihaela Campan, Daniel J Weisenberger, Peter W Laird, Kimberly D Siegmund and Ite A Laird-Offringa

    Citation: Molecular Cancer 2008 7:62

    Content type: Research

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  20. Chromatin-associated histone H2AX is a key regulator of the cellular responses to DNA damage. However, non-nucleosomal functions of histone H2AX are poorly characterized. We have recently shown that soluble H2...

    Authors: Ying Liu, Joshua A Parry, Anna Chin, Stefan Duensing and Anette Duensing

    Citation: Molecular Cancer 2008 7:61

    Content type: Research

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  21. Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria-derived activator of caspase (Smac/DIABLO) in enhancing the apoptosis-inducing poten...

    Authors: Tamer E Fandy, Sharmila Shankar and Rakesh K Srivastava

    Citation: Molecular Cancer 2008 7:60

    Content type: Research

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  22. Authors: Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Veronica Giunta, Antonella Rapisarda, Elisa Tricarichi, Marco Miceli, Rosario Angelica, Agata Grillo, Barbara Banelli, Isabella Defferari, Stefano Forte, Alessandro Laganà…

    Citation: Molecular Cancer 2008 7:59

    Content type: Erratum

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    The original article was published in Molecular Cancer 2008 7:52

  23. Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating t...

    Authors: Luigi Scotto, Gopeshwar Narayan, Subhadra V Nandula, Shivakumar Subramaniyam, Andreas M Kaufmann, Jason D Wright, Bhavana Pothuri, Mahesh Mansukhani, Achim Schneider, Hugo Arias-Pulido and Vundavalli V Murty

    Citation: Molecular Cancer 2008 7:58

    Content type: Research

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  24. Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD+ and arginine exert this effect by acting as signaling molecules, while car...

    Authors: Adrian K Arakaki, Roman Mezencev, Nathan J Bowen, Ying Huang, John F McDonald and Jeffrey Skolnick

    Citation: Molecular Cancer 2008 7:57

    Content type: Research

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  25. Photodynamic therapy (PDT) involves the administration of a tumor-localizing photosensitizing drug, which is activated by light of specific wavelength in the presence of molecular oxygen thus generating reacti...

    Authors: Ramaswamy Bhuvaneswari, Yik Y Gan, Sasidharan S Lucky, William WL Chin, Seyed M Ali, Khee C Soo and Malini Olivo

    Citation: Molecular Cancer 2008 7:56

    Content type: Research

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  26. Histone deacetylase inhibitors (HDACi) are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. Neuroblastoma (NB) i...

    Authors: Annick Mühlethaler-Mottet, Roland Meier, Marjorie Flahaut, Katia Balmas Bourloud, Katya Nardou, Jean-Marc Joseph and Nicole Gross

    Citation: Molecular Cancer 2008 7:55

    Content type: Research

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  27. Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization....

    Authors: Kristina Heyne, Katrin Schmitt, Daniel Mueller, Vivienne Armbruester, Pedro Mestres and Klaus Roemer

    Citation: Molecular Cancer 2008 7:54

    Content type: Research

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  28. Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of β-catenin in parathyroid adenomas from patients with primary hyperparathyroidism...

    Authors: Peyman Björklund, Daniel Lindberg, Göran Åkerström and Gunnar Westin

    Citation: Molecular Cancer 2008 7:53

    Content type: Research

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  29. The General Transcription Apparatus (GTA) comprises more than one hundred proteins, including RNA Polymerases, GTFs, TAFs, Mediator, and cofactors such as heterodimeric NC2. This complexity contrasts with the ...

    Authors: Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Veronica Giunta, Antonella Rapisarda, Elisa Tricarichi, Marco Miceli, Rosario Angelica, Agata Grillo, Barbara Banelli, Isabella Defferari, Stefano Forte, Alessandro Laganà…

    Citation: Molecular Cancer 2008 7:52

    Content type: Research

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  30. Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying freque...

    Authors: Helena Zientek-Targosz, Dimiter Kunnev, Lesleyann Hawthorn, Mikhail Venkov, Sei-Ichi Matsui, Richard T Cheney and Yuri Ionov

    Citation: Molecular Cancer 2008 7:51

    Content type: Research

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  31. Bortezomib, a specific and selective inhibitor of the 26S proteasome with antitumor activity against a wide range of malignancies, has been approved for the treatment of relapsed or refractory multiple myeloma...

    Authors: Valérie Combaret, Sandrine Boyault, Isabelle Iacono, Stéphanie Brejon, Raphaël Rousseau and Alain Puisieux

    Citation: Molecular Cancer 2008 7:50

    Content type: Research

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  32. Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly aggressive soft tissue tumors showing complex chromosomal aberrations. In order to identify recurrent chromosomal regions of gain and loss,...

    Authors: Stine H Kresse, Magne Skårn, Hege O Ohnstad, Heidi M Namløs, Bodil Bjerkehagen, Ola Myklebost and Leonardo A Meza-Zepeda

    Citation: Molecular Cancer 2008 7:48

    Content type: Research

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  33. Antisense (AS) induced down-regulation of uPAR in ACCS adenoid-cyctic carcinoma cells decreased the cellular adhesion and invasion on various extracellular matrices. Additionally, ACCS-AS cells showed an incre...

    Authors: Samah Abu-Ali, Abbas Fotovati and Kanemitsu Shirasuna

    Citation: Molecular Cancer 2008 7:47

    Content type: Research

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  34. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a cell adhesion molecule expressed in a variety of cell types is a putative tumor suppressor gene. Alternative splicing of CEACAM1 generates...

    Authors: Shikha Gaur, John E Shively, Yun Yen and Rajesh K Gaur

    Citation: Molecular Cancer 2008 7:46

    Content type: Research

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  35. Hashimoto Thyroiditis (H.T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid d...

    Authors: Karen Denning, Paul Smyth, Susanne Cahill, Jinghuan Li, Richard Flavin, Sinead Aherne, John J O' Leary and Orla Sheils

    Citation: Molecular Cancer 2008 7:44

    Content type: Research

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  36. Previous findings have suggested that epigenetic-mediated HLA-G expression in tumor cells may be associated with resistance to host immunosurveillance. To explore the potential role of DNA methylation on HLA-G ex...

    Authors: Laura Menendez, L DeEtte Walker, Lilya V Matyunina, Kimberly A Totten, Benedict B Benigno and John F McDonald

    Citation: Molecular Cancer 2008 7:43

    Content type: Research

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  37. Gefitinib (Iressa)–a specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase–has been shown to suppress the activation of EGFR signaling required for cell survival and proliferation in no...

    Authors: Yukio Nishimura, Kiyoko Yoshioka, Biborka Bereczky and Kazuyuki Itoh

    Citation: Molecular Cancer 2008 7:42

    Content type: Research

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  38. In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas ...

    Authors: François Ducray, Ahmed Idbaih, Aurélien de Reyniès, Ivan Bièche, Joëlle Thillet, Karima Mokhtari, Séverine Lair, Yannick Marie, Sophie Paris, Michel Vidaud, Khê Hoang-Xuan, Olivier Delattre, Jean-Yves Delattre and Marc Sanson

    Citation: Molecular Cancer 2008 7:41

    Content type: Research

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  39. The proteasome inhibitor bortezomib can inhibit activation of the transcription factor NF-κB, a mechanism implicated in its anti-neoplastic effects observed in mantle cell lymphoma (MCL). However, NF-κB can be...

    Authors: David T Yang, Ken H Young, Brad S Kahl, Stephanie Markovina and Shigeki Miyamoto

    Citation: Molecular Cancer 2008 7:40

    Content type: Research

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  40. We have used a mouse model based on overexpression of c-Myc in B cells genetically engineered to be self-reactive to test the hypothesis that farnesyl transferase inhibitors (FTIs) can effectively treat mature B ...

    Authors: Kenneth A Field, Soratree Charoenthongtrakul, J Michael Bishop and Yosef Refaeli

    Citation: Molecular Cancer 2008 7:39

    Content type: Research

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  41. An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex®) is mediated primarily via the inhibition of COX-2. We have investigate...

    Authors: Huan-Ching Chuang, Adel Kardosh, Kevin J Gaffney, Nicos A Petasis and Axel H Schönthal

    Citation: Molecular Cancer 2008 7:38

    Content type: Research

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  42. AMP-activated protein kinase (AMPK) is a known physiological cellular energy sensor and becomes phosphorylated at Thr-172 in response to changes in cellular ATP levels. Activated AMPK acts as either an inducer...

    Authors: Purna Mukherjee, Tiernan J Mulrooney, Jeremy Marsh, Derek Blair, Thomas C Chiles and Thomas N Seyfried

    Citation: Molecular Cancer 2008 7:37

    Content type: Research

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  43. Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease. In this concept, association ...

    Authors: Dominique Bernard-Gallon, Rémy Bosviel, Laetitia Delort, Luc Fontana, Alain Chamoux, Nadège Rabiau, Fabrice Kwiatkowski, Nasséra Chalabi, Samir Satih and Yves-Jean Bignon

    Citation: Molecular Cancer 2008 7:36

    Content type: Research

    Published on:

  44. MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable dise...

    Authors: Alexandros Laios, Sharon O'Toole, Richard Flavin, Cara Martin, Lynne Kelly, Martina Ring, Stephen P Finn, Ciara Barrett, Massimo Loda, Noreen Gleeson, Tom D'Arcy, Eamonn McGuinness, Orla Sheils, Brian Sheppard and John O' Leary

    Citation: Molecular Cancer 2008 7:35

    Content type: Research

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  45. Metastatic melanoma is a severe disease. Few experimental animal models of metastatic melanoma exist. MeLiM minipigs exhibit spontaneous melanoma. Cutaneous and metastatic lesions are histologically similar to...

    Authors: Giorgia Egidy, Sophia Julé, Philippe Bossé, Florence Bernex, Claudine Geffrotin, Silvia Vincent-Naulleau, Vratislav Horak, Xavier Sastre-Garau and Jean-Jacques Panthier

    Citation: Molecular Cancer 2008 7:34

    Content type: Research

    Published on:

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